Session Information
Date: Monday, June 20, 2016
Session Title: Parkinson's disease: Non-motor symptoms
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate whether P100 latency of pattern reversal visual evoked potential (PR-VEP) can predict the development of visual hallucination (VH) in Parkinson’s disease (PD).
Background: VH is often observed in PD, and visual dysfunction is assumed to be associated with VH, as our previous study had shown*. PR-VEP detects abnormalities in the visual pathway to the primary visual cortex. P100 component of PR-VEP originates from the lamina 2/3 in the primary visual cortex.
Methods: 99 consecutive PD patients in whom PR-VEP test had been performed were analyzed. Among them, subjects with current or previous VH at the enrollment were assigned to VH group (n=37) and subjects without VH were assigned to non-VH group (n=62). P100 latency was compared between the two groups. To elucidate whether P100 latency can predict ensuing VH development, non-VH group patients who have never developed VH (n=48) were divided into two subgroups at the median of P100 latency (110.0 msec), and a survival time analysis was performed to compare the time to VH occurrence between the subgroups.
Results: P100 latency was significantly prolonged in VH group (119.8 ± 9.1 msec) compared to those in non-VH group (110.3 ± 8.6 msec) (p<0.0001). A survival time analysis in non-VH group showed that VH occurred significantly earlier in the P100 upper half group than in the lower half group (Log-rank test p=0.0007). Cox hazard models demonstrated that P100 latency was statistically significant risk factors with age-adjusted hazard ratio of 14.3 (95% CI, 3.0-69.2).
Conclusions: P100 latency was prolonged in PD with VH, suggesting that VH was associated with the impairment of projection to the lamina 2/3 in the primary visual cortex. In addition the survival time analysis showed that extended P100 latency could be a predictor of VH in PD.
*10th International Congress on Non-Motor Dysfunctions in Parkinson’s disease and Related Disorders (Niece, 2014).
To cite this abstract in AMA style:
M. Kohsaka, T. Oeda, A. Umemura, S. Tomita, K. Park, K. Yamamoto, H. Sugiyama, H. Sawada. P100 latency of pattern reversal visual evoked potential and visual hallucination in Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/p100-latency-of-pattern-reversal-visual-evoked-potential-and-visual-hallucination-in-parkinsons-disease/. Accessed May 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/p100-latency-of-pattern-reversal-visual-evoked-potential-and-visual-hallucination-in-parkinsons-disease/