Early-onset Parkinson’s disease in seven patients with heterozygosity for parkin mutation
Objective: To present and discuss a series of 7 patients with early-onset Parkinson’s Disease and heterozygosity for PARK2 mutation. Background: Parkin mutation in homozygosity or…Early-onset parkinsonism and epilepsy: A Tunisian family carrying a novel SYNJ1 mutation
Objective: We report two siblings from a Tunisian family with juvenile Parkinsonism associated with tonic-clonic seizures and good response to levodopa therapy carrying a novel…Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors
Objective: In this study we aim to elucidate the role of Kif5b motor subunit in the nigrostriatal pathway. We have generated different conditional knockout mice…SIRT1/AMPK pathway is involved in neuroprotective effects of resveratrol on MPTP-induced neuron loss
Objective: The present study was carried out to observe the neuroprotective effects of RV on MPTP-induced mouse model of PD, and explore its potential neuroprotective…A review of modifiers of Parkinsonism in the Leucine-rich repeat kinase 2 (LRRK2) population
Objective: To review and examine the most current identified modifiers of Parkinsonism in the LRRK2 population. Background: LRRK2 is a protein with multiple domains and…Lack of TMEM230 mutations in patients with familial and sporadic Parkinson’s disease in a Taiwanese population
Objective: To confirm the role of mutations in transmembrane protein 230 (TMEM230) in a large number of PD patients and controls in a Taiwanese population.…Clinical evaluation of genetic changes of polymerase chain reaction in patients with PD at early stage
Objective: To assess the clinical feature of genetic changes in PARK1 (α-synuclein) and PARK2 with the help of PCR in patients with Parkinson’s disease and…Downregulation of blood serum microRNA 29 family in patients with Parkinson’s disease
Objective: The aims of the present study were to profile the expression of microRNA29 family (miR-29s) in blood serum from patients with PD vs unaffected…Polymorphisms of glutamatergic system genes are associated with levodopa-induced dyskinesia in Parkinson’s disease
Objective: We aimed to study the association between glutamatergic system gene polymorphisms (SLC1A2 – gene, coding excitatory acids transporter, and GRIN2A gene, coding a subunit…Tef polymorphism predicts the decline of sleep disturbances in Parkinson’s disease
Objective: Circadian dysfunction may contribute to the etiology of motor and non-motor symptoms of Parkinson’s disease (PD). The influence of polymorphisms of Cry1 rs2287161, Cry2…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.