Widespread distribution and abundant accumulation of alpha-synuclein oligomers in multiple system atrophy brain
Objective: To examine the distribution of alpha-synuclein (αSyn) oligomers as an early pathological change in multiple system atrophy (MSA) brains. Background: Although severe neuronal loss…Maladaptive Nigrovagal Neuronal Plasticity Causes Ascending Alpha-Synucleinopathy in a Novel Environmental Toxin Based Rat Model of Parkinsonism
Objective: Test the hypothesis that unilateral chemogenetic inhibition of the nigrovagal pathway in the subthreshold Paraquat (P) + dietary lectin (L) exposure rat model of…Alpha-synuclein interacts with BAF complex in nucleus
Objective: This study aims to uncover the prospective partner of αS in nucleus. Background: In neuronal cells, large part of alpha-synuclein (αS) localize at presynaptic…Central Insulin Resistance Index is Independent of Peripheral Insulin Resistance in Parkinson’s disease
Objective: To correlate brain insulin signalling with peripheral insulin resistance using neuronally derived blood exosomes in patients with Parkinson's Disease (PD) Background: Insulin signaling abnormalities may…Co-administration of levodopa and zonisamide reduces the serotonin transporter expression in a rat model of Parkinson’s disease
Objective: To investigate the change of striatal serotonergic system according to the administration of levodopa and zonisamide (ZNS) on the striatal serotonergic system, we analyzed the…The role of lipid metabolism in mouse models of Parkinson’s disease
Objective: To investigate the role of lipid metabolism and the effect of blocking carnitine palmitoyl-transferase 1 (CPT1) in toxic and genetically mouse models of Parkinson’s…Experimental model of developing of Parkinson’s disease
Objective: Analyzing the reserpine model of Parkinsonian syndrome Background: There are several experimental models of Parkinson's disease: reserpine, methamphetamine, 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - substances that…Motor compensation in Parkinson’s disease: a multimodal neuroimaging study
Objective: To study motor compensation mechanisms in Parkinson's disease. Background: Whereas akinesia in Parkinson's disease (PD) is linked to dopaminergic neurons death and striatal dopamine depletion,…Functional Proteomic Analysis of Leukocytes from Parkinson’s Disease Patients: A Clinical Perspective on Biomarkers Identification
Objective: The aim of this work was to identify proteomic profiles associated with specific Parkinson’s disease (PD) clinical groups in leukocytes of patients from Rio…Microglia as modulators of exosomal alpha-synuclein transmission
Objective: It is highly desirable to make clear the underlying mechanism of exosomes-involved communication in the synucleinopathy pathogenesis. Background: Emerging evidence suggests that exogenous pathogenic…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.