GBA haploinsufficiency accelerated alpha synuclein pathology with altered lipid metabolism in a premotor model of Parkinson’s disease
Objective: To make Parkinson’s disease (PD) mice model and investigate the mechanism how glucocerebrosidase (gba) heterozygous mutations contribute to asyn pathology and development of PD.…Reduced vesicular storage of catacholamines enhance MPTP-induced death of dopaminergic neurons in locus coeruleus and olfactory bulb
Objective: In this study, we employed heterozygous knockout (vmat2+/-) mice to investigate the influence of reduced vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-impaired dopaminergic neurons…Status of riding bicycle and reasons for cessation of cycling in patients with Parkinson disease: A Japanese single center cross-sectional survey
Objective: To investigate the current status of riding bicycle and the reasons for cessation of cycling in patients with Parkinson disease (PD). Background: The “bicycle…T lymphocytes in Parkinson’s disease pathogenesis and therapy: A systematic review
Objective: A systematic literature review was conducted to synthesize the current state of knowledge on the role of T lymphocytes in Parkinson’s disease (PD) pathology…Identification of putative serum biomarkers for parkin-related Parkinson’s disease by metabolome analysis
Objective: Parkin is known as the causative gene of autosomal recessive familial Parkinson’s disease (parkin-PD). It remains unclear how parkin dysfunction associates with the dopaminergic…Red cell distribution with levels in Parkinson’s disease patients
Objective: Parkinson’s Disease is a neurodegenerative disorder caused by oxidative stress, protein changes and mitochondrial disfunction. Lately, it has been suggested that inflammatory cytokine levels…Determination of falling direction in Parkinson’s disease patients using a wearable sensor
Objective: The aim of this study is to objectively detect falls and their direction in Parkinson’s disease (PD) patients during everyday activities. Background: Falling is…Bone health and laboratorial correlations of Vitamin D in Parkinson’s disease
Objective: To evaluate the correlation between levels of 25 (OH)D (Vitamin D) and Bone Mineral Density (BMD) in a parkinsonian population. Background: Considering a limiting…Soluble TREM2 and Central and Peripheral Inflammatory Biomarkers in Parkinson’s Disease
Objective: Given that Parkinson's disease (PD) may be associated with TREM2 and given that a soluble TREM2 (sTREM2) isoform has been described as elevated in…Deletion of GBA2 in neuronopathic Gaucher’s disease medaka can’t rescue the phenotype
Objective: This study was performed to determine the pathological role of GBA2 in the CNS in GD and GBA1-related PD. Background: Parkinson’s disease (PD) is…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.