Synthesis and pharmacological evaluation of 16-aryldieno steroids as anti-parkinsonian agents in LPS induced Neuroinflammation Model of Rat
Objective: The present study is aimed at design and synthesis of new therapeutically useful steroidal neuroprotective derivatives as anti-parkinsonian agents. The new 16-aryldieno steroidal derivatives…Parkinsonism in the very old – A clinicopathological study
Objective: To identify, spectrum of Parkinson variants, clinical features and course of disease in age > 80 year onset cases. Background: Old age is the…Metabolomic biomarkers strongly differentiate PD from healthy controls (HCs) in BioFIND study* specimens
Objective: To determine if metabolomic analysis - untargeted profiling of small-molecule (<1.5 kDalton) biochemical constituents - can yield useful diagnostic biomarkers of PD using CSF…Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder.
Objective: Here we tested if p-syn deposits can be detected with the same approach in patients affected with idiopathic RBD (iRBD), as an early histopathological…Longitudinal study of freezing of gait in patients with Parkinson’s disease
Objective: We conducted a prospective hospital based cohort study to investigate the incidence of Freezing of gait (FOG) and variables associated with onset of FOG…Axial signs in early-stage Parkinson’s disease : an influence of the genotype ?
Objective: To assess the association between the genotype and the axial signs. Background: Regarding the onset of axial signs in Parkinson’s Disease (PD), heterogeneity has…Mutant DNAJC13 modulates accumulation and toxicity of alpha-synuclein through altered endosomal trafficking in cell and fly models of Parkinson’s disease
Objective: The aim of this study is to investigate the effect of DNAJC13 mutation on the vesicle transport, α-synuclein (αSYN) distribution/catabolism, and neurodegeneration using a…Disease-modification in Translational Models of Parkinson’s disease by the Rho Kinase Inhibitor Fasudil
Objective: To evaluate the therapeutic potential of the Rho Kinase (ROCK) inhibitor Fasudil in translational models of Parkinson’s disease (PD). Background: There is still a…The novel Parkinson´s disease locus RIT2 and alpha-synuclein function in intersecting pathways
Objective: We aim to describe the molecular pathways at the crossroad of etiology and susceptibility in PD, focusing on Rin, coded by the recently associated…Increased and symmetric expression of rigidity in early Parkinson’s disease with abnormal REM sleep without atonia
Objective: The purpose of this study was to compare the level and bilateral expression of upper arm rigidity between people with early stage Parkinson’s disease…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.