3D Markerless Video-Based Assessment of Lower Extremity Dystonia in X-linked Dystonia Parkinsonism and DYT-TOR1A
Objective: To evaluate whether markerless video analysis can extract quantitative motor features that reflect dystonia severity in X-linked dystonia parkinsonism (XDP). Background: XDP is an…Altered Glia Limitans Structure and Function in Parkinson’s Disease and Multiple System Atrophy
Objective: To investigate functional alterations of the glia limitans and the consequent changes in glymphatic system dynamics and CD4⁺ T cell infiltration in the disease-affected…Increased Pre-Alpha EEG Functional Connectivity Forecasts Future Cognitive Decline in Parkinson’s Disease
Objective: To evaluate whether resting-state EEG functional connectivity (rsEEG-FC) forecasts cognitive decline three years later in Parkinson’s disease (PD). Background: Cognitive performance and trajectories of…Dynamic and Multimodal Prediction of Phenoconversion to Cerebellar Multiple Sytem Atrophy among Sporadic Late-Onset Cerebellar Ataxia
Objective: To dynamically predict phenoconversion from a sporadic late-onset cerebellar ataxia (SLOCA) phenotype to MSA-C. Background: Cerebellar multiple system atrophy (MSA-C) is diagnosed according to…Elevated Myeloperoxidase Levels and Activity as Potential Biomarkers for Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess the utility of the myeloperoxidase enzyme level as a diagnostic biomarker in Parkinson’s disease. Background: Myeloperoxidase (MPO) contributes to Parkinson’s disease (PD)…Systemic Inflammation and Cerebral Small Vessel Disease in Progressive Supranuclear Palsy
Objective: To assess the cerebral small vessel disease (CSVD) burden in progressive supranuclear palsy (PSP) and examine the relationships among peripheral inflammatory markers, CSVD imaging…Multi-Sequence MRI-Based Machine Learning Model for Differentiating Parkinson Disease (PD) from Multiple System Atrophy (MSA)
Objective: To develop a multi-sequence MRI-based machine learning model differentiating PD from MSA. Background: MRI protocols capable of distinguishing PD from MSA are greatly needed.…SIRT3 upregulation in nigral dopaminergic neurons preserves motor circuit integrity for anti-sarcopenia
Objective: To determine whether enhancing resilience of substantia nigra dopaminergic neurons preserves motor circuit integrity. Background: Degeneration and dysfunction of substantia nigra pars compacta (SNpc)…Unravelling the neural correlates of visual cueing in Parkinson’s disease
Objective: Visual cueing can compensate for impaired automatic gait control in Parkinson's disease (PD) patients experiencing Freezing of Gait (FOG) by engaging goal-directed motor behaviour1.…Cholinergic Pathway Degeneration Predicts Differential Phenoconversion to Synucleinopathies in Idiopathic REM Sleep Behavior Disorder
Objective: This cross-sectional and longitudinal study aimed to elucidate the pattern of cholinergic white matter pathway degeneration underlying the phenoconversion trajectories in iRBD patients. Background:…
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