Early synaptic loss and synaptic instability in a mouse model of prodromal Parkinson’s disease
Objective: In order to elucidate very early pathologis of Parkinson’s disease (PD), we focused on synaptic pathologies in a newly developed mouse model of prodromal…Evaluation of the relationship between Leucine-rich repeat kinase 2 (LRRK2) S1647T variants and smoking with risk of Parkinson’s Disease in the Singapore population
Objective: To investigate whether cigarette smoking influences the relationship between S1647T variants and risk of PD in the Singapore population. Background: Case-control studies in southern…Interaction between MAPT H1 and APOE4 in early Parkinson’s Disease
Objective: To define if the high risk MAPT allele of rs393152 (H1 haplotype) is associated with differences in brain structure, clinical presentation, progression or cognitive…Balance and gait analysis of GBA mutation carriers with Parkinson’s disease (PD)
Objective: To use quantitative inertial sensor-based postural sway and gait analysis to determine potential differences in the pattern of balance and gait impairment in the…Novel GBA risk factor gene mutation p.W378R in a kindred with Gaucher’s disease and Parkinson’s disease
Objective: We undertook mutation analysis of the Glucocerebrosidase gene (GBA) gene in a large three-generational Australian kindred consisting of some individuals with both type 1…PLA2G6-related juvenile-onset Parkinsonism: clinical features and cognitive profile in a cohort of Chinese patients
Objective: Among young or juvenile onset Parkinson (PD) patients, we assessed cognitive and clinical performances, comparing homozygotes and compound heterozygotes who carry PLA2G6 pathogenic mutations…Adult neurogenesis is impaired in pink1-/- zebrafish (Danio rerio)
Objective: To determine whether PINK1 deficiency impairs adult neurogenesis in a tractable vertebrate model of PINK1-related Parkinson's disease (PD). Background: PD is characterized by loss…MicroRNA expression misregulation in iPSC-derived dopaminergic neurons from sporadic and LRRK2-associated Parkinson disease patients
Objective: To investigate whether miRNA expression alterations occur in iPSC-derived DAn from sporadic PD (sPD) as well as monogenic LRRK2-associated PD patients. Background: MicroRNA (miRNA)…Computational and Biochemical analysis of lipid raft proteins: A new perspective approach to understand the progression of late onset Parkinson’s disease
Objective: In the current study we report mutations, particularly inPARK-7 gene and their impact on understanding the pathophysiology of Parkinson’s disease (PD); it also lays…Integrated whole exome sequencing and chromosomal microarray in familial Parkinson’s disease
Objective: To determine whether whole exome sequencing (WES) plus chromosomal microarray analysis (CMA) yield a genetic etiology in a cohort of 110 individuals with familial…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.