Impaired topographic organization in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease
Objective: To investigate the disrupted topographic organization in a cohort of cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson’s disease (PDAR), and its potential relationships with…Study on feasibility to develop a central nervous system (CNS) Leucine-rich repeat kinase 2 (LRRK2) PET tracer
Objective: To assess feasibility of developing a CNS LRRK2 PET tracer. Background: LRRK2 enzyme belongs to the leucine-rich repeat kinase family. Pathogenic mutations in the…Potential indicator of antiparkinsonian drug efficacy: an attempt to explore imaging findings
Objective: To clarify the Single photon emission computed tomography (SPECT) findings for evaluating currently unknown antiparkinsonian drug efficacy in Parkinson’s disease (PD) patients. Background: Little…Semi-automated segmentation and quantification of the substantia nigra depigmentation in Parkinson’s disease – a multicentre case control MRI study in 284 participants
Objective: To provide a semi-automated segmentation and quantification method of the changes in the substantia nigra (SN) in Parkinson’s disease (PD) using neuromelanin (NM)-sensitive MRI…Alterations of cortical metabotropic glutamate receptor-mediated signaling in patients with Parkinson’s disease
Objective: To evaluate expression of brain metabotropic glutamatergic receptor 5 and the relationship with clinical measures in Parkinson’s disease patients. Background: Metabotropic glutamate receptor 5…Dopaminergic and Metabolic Imaging in Parkinson’s Disease motor subtypes and their relations to parkinsonian tremor
Objective: The mechanism underlying rest tremor of Parkinson’s disease(PD), while likely differing from those underlying akinesia and rigidity, remains unclear. The objective of this study…Effects of age, motor severity and disease duration on finger tapping movement under dual-task in Parkinson’s disease patients
Objective: Twenty-six patients with Parkinson's disease (PD) (68.0 ± 8.0 years old; mean ±SD) underwent finger tapping (FT) on the symptom-predominant side during pronation-supination movement…Brain network activation (BNA): A new biomarker for Parkinson’s disease?
Objective: We aimed to assess the ability of the Brain Network Activation (BNA) EEG analysis algorithm to differentiate between early-stage Parkinson’s disease (PD) patients and…What happens when I watch a ballet? Preliminary fMRI findings on somatosensory empathy in Parkinson Disease
Objective: To investigate the neural components of the mirror sensor-motor system recruited by a dance movement in a motor disorder, such as PD is. Background:…Remote patient monitoring with a digital biomarker approach generates clinically distinctive and meaningful sensor feature data in Parkinson’s disease: Differential relationships with MDS-UPDRS-III, PDQ-39 and DaT-SPECT
Objective: To determine whether sensor features derived from remote smartphone testing in Parkinson’s disease (PD) predicted clinical, quality of life and biomarker measures collected in…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.