About Data Missingness in Wearable Monitoring of Parkinson’s Disease
Objective: To examine how adherence and data completeness vary throughout the day in wearable monitoring of people with Parkinson’s disease (PwPD), and whether missing data patterns are associated with disease severity. Background: Wearable devices…Physical Activity is Associated with Attenuated Motor and Cognitive Progression in Parkinson’s Disease
Objective: To determine whether physical activity (PA) modifies the rate of motor and cognitive progression in Parkinson’s disease (PD) and to identify specific components of…IncobotulinumtoxinA for the Treatment of Lower Limb Spasticity in Children and Adolescents with Cerebral Palsy Evaluation of Lower Limb IncobotulinumtoxinA Efficacy (ELLIE)
Objective: To investigate the use of incobotulinumtoxinA in the treatment of lower limb spasticity in children and adolescents with cerebral palsy (CP). Background: Spasticity associated…A Specific Neuronal Subpopulation in Globus Pallidus External Segment Mediates the Pathogenesis of Dyskinesia in Parkinson’s Disease
Objective: To clarify the causality between neuronal activity in globus pallidus external segment (GPe) and levodopa-induced dyskinesia (LID), and further ascertain the specificity of this…Identification of Digital Measures of Motor Progression from In-Clinic Assessments in Early Parkinson’s Disease for Composite Digital Biomarkers: Results from WATCH-PD
Objective: To identify sensor-based digital measures of motor function that exhibit reliability, association with MDS-UPDRS Part 3, and longitudinal progression in early-stage Parkinson’s disease (PD),…Dorsal STN and Zona Incerta Stimulation as a Strategy to Reduce Dyskinesia after STN-DBS: A Case Series with Literature Reviews
Objective: These case series illustrate practical programming strategies and clinical decision-making in real-world DBS practice using the concept of stimulating the dorsal STN or ZI…Rest Tremor does Not Predict Response to Focused Ultrasound Thalamotomy in Essential Tremor and Dystonic Tremor
Objective: To investigate whether pre-treatment rest tremor severity predicts outcomes in a cohort of patients with essential tremor/essential tremor plus (ET/ET+) and dystonic tremor (DT).…External Validation of a Machine Learning Classifier for Motor Progression in Parkinson’s Disease
Objective: To externally validate a previously published machine learning (ML) classifier for predicting motor symptom progression in Parkinson’s disease (PD) using an independent clinical dataset.…Head Trauma History and Motor Phenotype in Early Parkinson’s Disease
Objective: To examine whether patients with Parkinson's disease (PD) and a history of head trauma (HT) differ from those without HT in terms of motor…Cerebellar cholinergic denervation relates to impaired gait and cerebellocortical resting-state functional connectivity in Parkinson disease
Objective: The purpose of this cross-sectional study was to investigate the cholinergic denervation of the cerebellum and its contribution to impaired gait and cerebellocortical resting-state…
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