MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2016 International Congress

    Parkinson’s disease-associated Miro1 mutants cause mitochondrial dysfunction

    D. Grossmann, D. Scheibner, J. Fitzgerald, W. Mätzler, L. Burbulla, R. Krüger (Belvaux, Luxembourg)

    Objective: In the present study we dissected the role of the first PD-associated mutations in RhoT1, the gene encoding for Miro1. Background: Commonly involved pathogenic…
  • 2016 International Congress

    A descriptive study on the safety and feasibility of mesenchymal stem cell therapy for Parkinson’s disease: A case series

    M.J.O.V. Buensalido, J.J.A. Tiongson (Pasig City, Philippines)

    Objective: To describe the incidence and severity of infusion-related adverse events of mesenchymal stem cells (MSC) for Parkinson's disease in patients who underwent treatment. Background:…
  • 2016 International Congress

    Polyethylenimine (PEI) nanoparticle-mediated delivery of siRNA to silence neuronal gene expression of alpha-synuclein in a mouse model of Parkinson’s disease

    C. Helmschrodt, A. Bauer, S. Höbel, S. Schöniger, S.A. Fietz, A. Aigner, A. Richter, F. Richter (Leipzig, Germany)

    Objective: To develop novel therapeutic strategies for movement disorders by interfering with neuronal gene expression, PEI nanoparticle-mediated delivery of RNA was investigated in vivo. Background:…
  • 2016 International Congress

    Gene delivery of AAV2-neurturin for patients with Parkinson’s disease: A meta-analysis

    A.G. Almraezy, H. Ahmed, M. Elnenny, A. Negida (Cairo, Egypt)

    Objective: The objectives of this meta-analysis are: 1) to investigate the efficacy of AAV2-neurturin gene delivery for patients with Parkinson's disease; 2) to compare AAV2-neurturin…
  • 2016 International Congress

    Two-step induction of dopaminergic neurons – Differentiation of leukapharesis-derived mesenchymal stem cells

    S.I. El-Jaafary, M.M. Abdel-Dayem, N.M. Salama, H. Gabr, A.S. Abdelhafiz, Z.M. Ismail (Cairo, Egypt)

    Objective: The aim of the present study is to establish a reproducible in-vitro protocol to induce the human MSCs derived from peripheral blood, after mobilization…
  • 2016 International Congress

    Differentiated versus undifferentiated mesenchymal stem cell therapy in paraquat model of Parkinson’s disease

    S.I. El-Jaafary, H.S. Abdel Tawab, M.Y. Elwash, H. Gabr, H.M. Saad Eldien (Cairo, Egypt)

    Objective: To investigate the effect of undifferentiated versus differentiated CD34 stem cells series on paraquat model of PD and to elucidate the mechanism of action…
  • 2016 International Congress

    Gene expression analysis using the Parkinson’s disease map reveals early effects of alpha-synuclein on PD pathogenesis

    S. Gebel, A. Ashrafi, P. Garcia, M. Ostaszewski, P. Gawron, L. Vallar, N. Nicot, T. Kaoma, R. Balling, E. Glaab, M. Buttini (Esch-sur-Alzette, Luxembourg)

    Objective: The identification of early disease markers for Parkinson's disease (PD) is essential, since the disease is already in an advanced state when motor symptoms…
  • 2016 International Congress

    Integrity of the superior longitudinal fascicle and its relationship with anticipatory postural adjustments in people with Parkinson’s disease and freezing of gait

    A.C. de Lima-Pardini, T.Q. Freitas, D.B. Coelho, C.C. Boffino, C. Souza, R. Brandt, E.R. Barbosa, L.A. Teixeira, E. Amaro Jr. (São Paulo, Brazil)

    Objective: To assess the integrity of the Superior Longitudinal Fascicle (SLF) and its relationship with the Anticipatory Postural Adjustments (APAs) of step initiation in people…
  • 2016 International Congress

    Relationships of cognitive functions and psychiatric symptoms with motor phenotypes in patients with untreated early-stage Parkinson’s disease

    H. Terashi, Y. Ishimura, T. Taguchi, H. Mitoma, H. Aizawa (Tokyo, Japan)

    Objective: It has been shown that the clinical types of Parkinson's disease (PD) based on motor symptoms include motor phenotypes of postural instability and gait…
  • 2016 International Congress

    Staging and clinical correlates of cortical thinning in Parkinson’s disease

    H. Wilson, F. Niccolini, C. Pellicano, P. Piccini, M. Politis (London, United Kingdom)

    Objective: By using a novel disease staging model to investigate the progression and clinical associations of cortical thinning in Parkinson's disease (PD) patients. Background: The…
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