Session Information
Date: Tuesday, June 21, 2016
Session Title: Parkinson's disease: Pathophysiology
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: It has been shown that the clinical types of Parkinson’s disease (PD) based on motor symptoms include motor phenotypes of postural instability and gait difficulty PD (PIGD PD) and tremor-dominant PD (TD PD). While associations between non-motor symptoms and specific motor phenotypes have also been suggested, this possibility remains largely uninvestigated. Our study objective was to clarify the relationships of cognitive functions and psychiatric symptoms with motor phenotypes in patients with untreated early-stage PD.
Background: Studies of motor phenotypes of PD revealed the characteristics of PIGD PD to include 1) poor prognosis with rapid progression, 2) late onset, and 3) poor response to levodopa. Associations of PIGD PD with dementia, depression, and anosmia have also been suggested, but there is no consensus as to these possible relationships.
Methods: The subjects were 35 consecutive patients with untreated early-stage PD (21 men, 14 women; mean age, 66.2 ± 6.9 years). The study endpoints were Mini Mental State Examination (MMSE), Beck Depression Inventory-II (BDI-II), Clock Drawing Test (CDT), Frontal Assessment Battery at bedside (FAB), Trail Making Test (TMT) B/A, Behavioral Assessment of the Dysexecutive Syndrome (BADS), and Odor-Stick Identification Test for Japanese (OSIT-J). We classified the subjects into three subtypes, PIGD PD, TD PD, and indeterminate motor phenotype PD. The subjects then underwent detailed examinations.
Results: The results for the endpoints related to cognitive functions and psychiatric symptoms showed no significant differences among the motor phenotypes. Regarding the relationship of each endpoint to PIGD and tremor scores, on the other hand, there was a significant positive correlation between BDI-II and the PIGD score (R = 0.378, P < 0.05) and between Apathy scale and the PIGD score (R = 0.408, P < 0.05). However, the OSIT-J scores in PIGD PD were significantly lower than those in TD PD, and there was a significant negative correlation between OSIT-J and the PIGD score (R = -0.443, P < 0.01).
Conclusions: In patients with untreated early-stage PD, there were no significant differences in cognitive functions or psychiatric symptoms among the motor phenotypes. However, depression, apathy, and hyposmia showed significant associations with gait disturbance.
To cite this abstract in AMA style:
H. Terashi, Y. Ishimura, T. Taguchi, H. Mitoma, H. Aizawa. Relationships of cognitive functions and psychiatric symptoms with motor phenotypes in patients with untreated early-stage Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/relationships-of-cognitive-functions-and-psychiatric-symptoms-with-motor-phenotypes-in-patients-with-untreated-early-stage-parkinsons-disease/. Accessed February 18, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/relationships-of-cognitive-functions-and-psychiatric-symptoms-with-motor-phenotypes-in-patients-with-untreated-early-stage-parkinsons-disease/