Exposure-Response Analysis of Glovadalen in the ATLANTIS Phase II Study: Trial Simulation Explains Dose-Response for OFF Time in Parkinson’s
Objective: This analysis characterized the exposure-response (E-R) relationship of glovadalen (UCB0022) in the ATLANTIS Phase-IIa proof-of-concept study, to understand the apparent lack of dose-response for…Affective Symptom Burden in Individuals with Olfactory Dysfunction in the PREDICT-PD Cohort
Objective: To investigate associations between hyposmia (olfactory dysfunction) and affective symptom burden in PREDICT-PD participants. Background: Anxiety, depression, and hyposmia are common non-motor features of…Long-term outcomes and real-world implementation of adaptive deep brain stimulation in Parkinson’s disease
Objective: To evaluate long-term outcomes and real-world implementation of beta-guided adaptive deep brain stimulation (aDBS) in patients with Parkinson’s disease (PD), including clinical effects, longitudinal…Real-World Relationship Between Beta-Band LFP Activity and Motor States in Parkinson’s Disease
Objective: To evaluate the relationship between 10-minute averaged beta-band local field potential (LFP) activity recorded from implanted deep brain stimulation (DBS) systems and motor state…The Unholy Marriage Between Ogilvie Syndrome and Parkinson’s Disease
Objective: To demonstrate the dynamic interplay between advanced Parkinson’s disease (PD)–related colonic dysmotility and acute colonic pseudo-obstruction (ACPO; Ogilvie syndrome) and to highlight practical red…Comparability of Smartphone App and Booth Recordings for Robust Acoustic Speech Monitoring in Parkinson’s Disease
Objective: To assess the technical equivalence and scalability of remote app-based recordings against gold-standard laboratory conditions to identify reliable speech features suitable for longitudinal monitoring…A Case of Progressive Cerebellar Syndrome with Ataxia as a First Sign
Objective: To present a case of paraneoplastic cerebellar degeneration whose first sign was ataxia. Background: Paraneoplastic cerebellar degeneration (PCD) is a rare autoimmune syndrome that presents…App-Based Speech Assessment Differentiates PD and PSP: A Feasibility Study in Italian Speakers
Objective: To evaluate the feasibility of app-based speech assessment in Parkinson’s disease (PD) and progressive supranuclear palsy (PSP), and to explore group differences in speech…Clinical and Biomarker Trajectories in GBA1 Non-Manifesting Carriers With and Without α-Synuclein Seed Amplification Positivity
Objective: To characterize clinical and biomarker features of GBA1-NMC and evaluate whether CSF-αSynSAA status is associated with longitudinal clinical progression and phenoconversion. Background: Pathogenic variants…Does CANVAS mimic MSA-C
Objective: To describe the natural history of RFC1-related ataxia, identify discriminative features compared to MSA-C, and study their survival outcomes. Background: AAGGG intronic expansions in…
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