Critical path for Parkinson’s II: Global regulatory agencies support the use of dopamine transporter neuroimaging as an enrichment biomarker to enable clinical trials in early Parkinson’s disease
Objective: This presentation focuses on neuroimaging of the Dopamine Transporter as an enrichment biomarker in clinical trials of Parkinson's disease (PD). Background: The Critical Path…Improvement of saccade amplitude by the STN DBS and visual target eccentricity
Objective: To investigate whether or not the improvement of saccade amplitude by the subthalamic nucleus (STN) deep brain stimulation (DBS) is the same for to…Neuromelanin-MRI of substantia nigra subregions in Parkinson’s disease
Objective: To detect changes in the different subregions of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease (PD) and to correlate the…Spectral analysis of rapid eye movement (REM) sleep as a potential marker of neurodegenerative disease in REM sleep behavior disorder
Objective: To investigate whether spectral analysis at baseline in rapid eye movement (REM) sleep can differentiate patients with REM sleep behavior disorder (RBD) who will…Impact of chronic LD treatment on metabolism, blood flow and blood-brain barrier permeability in the 6-OHDA rat model
Objective: To determine the effects of chronic LD treatment and induction of dyskinesias on cerebral metabolism, blood flow and blood-brain barrier permeability in 6-OHDA rat…Multi-modal imaging in Parkinson’s disease patients with freezing of gait
Objective: The objective of the current study is to refine understanding of the pathophysiological mechanisms underlying freezing of gait (FOG) in Parkinson's disease (PD) using…Diffusion tensor metrics of thalamic degeneration and postural instability in Parkinson’s disease
Objective: The purpose of our study was to assess the relationship of diffusion tensor imaging (DTI) metrics and motor outcomes, with a specific emphasis on…Dopamine and task-dependent evolution of oscillatory activity in the subthalamic nucleus (STN) and coupling between the STN local field potential and muscle activity in Parkinson’s disease
Objective: To investigate how subthalamic nucleus local field potentials (STN-LFP) and coupling between STN-LFP and electromyogram (EMG) in static and phasic movements are modulated by…Cortical excitability in patients with Parkinson’s disease on levodopa carbidopa intestinal gel thereapy
Objective: To assess whether there are changes in short interval intracortical inhibition (SICI) that reflect changes in motor function and plasma levodopa levels in patients…Impaired temporal coupling of action and perception in Parkinson’s disease
Objective: To study in Parkinson's disease (PD) the dependence of saccadic and perceptual reaction times (SRT and PRT) upon the temporal asynchrony (TA) between central…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.