Evaluation of mitochondrial dysfunction in fibroblasts and iPSC-derived dopaminergic neurons of patients affected by Multiple System Atrophy
Objective: The aim of the present study is to investigate mitochondrial functioning in fibroblasts and iPSC-derived dopaminergic neurons of patients affected by Multiple System Atrophy…The phenotypic spectrum of patients with progressive supranuclear palsy
Objective: The aim of the this study to evaluate different modes of (initial) clinic type of patients with PSP. Background: Progressive supranuclear palsy (PSP) is…Differential diagnosis and progress monitoring in Progressive Supranuclear Palsy – a potential role of pulmonary function tests
Objective: To determine the utility of pulmonary function tests in the differential diagnosis and monitoring of disease progression of Progressive Supranuclear Palsy. Background: Pulmonary complications…Parkinsonism in Patients with Alzheimer Disease and Epileptic Seizures
Objective: This article present the specifics of the parkinsonism which is observed in patients with Alzheimer disease,diagnosed epilepileptic seizures,especially as a diferential diagnostic problem, followed for a…Development of a Clinician-reported Screening Tool to Identify Patients with Parkinson’s disease inadequately controlled on oral medications
Objective: To identify key clinical indicators for Parkinson disease (PD) patients inadequately controlled with oral medications or eligible for device-aided treatments. Background: Identifying patients with…Differentiating Parkinsonism with Spatio-temporal dynamics (real-time MRI) and Acoustics of Speech (spectrogram)
Objective: Differentially diagnosing subgroups in Parkinsonism for optimal rehabilitation thus designed study with real-time dynamic magnetic resonance imaging (MRI) and automated acoustic analysis Background: In Parkinsonism with…Movement Disorder Society – Clinical Diagnostic Criteria for Progressive Supranuclear Palsy
Objective: The International Parkinson and Movement Disorders Society-endorsed PSP Study Group aimed to provide an evidence- and consensus-based revision of the clinical diagnostic criteria for…Dynamic Instability and Stride Width in Parkinsonism
Objective: To compare differences in local dynamic stability (LDS) and its association with stride width in individuals with idiopathic Parkinson’s Disease (iPD), individuals with frontal…Results of a Phase 1, Single Ascending Dose, Placebo-Controlled Study of ABBV-8E12 in Patients with Progressive Supranuclear Palsy and Phase 2 Study Design
Objective: To present the results of a phase 1 study of ABBV-8E12 in subjects with Progressive Supranuclear Palsy (PSP) and design of a phase 2…Parkinsonism through astrocytic GABA induce motor symptoms
Objective: Although reactive gliosis is a prominent feature of PD, its role in pathogenesis has remained elusive. Here we show that aberrantly synthesized GABA from reactive astrocytes tonically inhibits neighboring dopaminergic neuronal firing in SNpc, reducing dopamine production and release, leading to parkinsonian motor symptoms. Background: Parkinsonism is a clinical syndrome of movement abnormalities seen in Parkinson’s disease (PD), which has been attributed to cell-autonomous mechanism of doparminergic neuronal death in the substantia nigra pars compacta (SNpc). Methods: To identify the…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.