Date: Monday, June 5, 2017
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: This article present the specifics of the parkinsonism which is observed in patients with Alzheimer disease,diagnosed epilepileptic seizures,especially as a diferential diagnostic problem, followed for a long period and there treatment.
Background: Presence of the signs of parkinsonism and epileptic seizures in patients with Alzheimer disease(AD) are observed.Epileptic seizures in elderly patients are rare but are not an unexpected.In patients with Alzcheimer disease important neurochemical changes occur,by lack of the enzyme o-acetyltranspherase,which can lead to lack od acetylcholine.
Methods: 31 patients (21 men and 10 women) with Alzheimer disease of which 6 with parkinsonism from this 4 with generalized tonic clonic seizures and 2 with motor automatisms were observed at the university neurology clinic in Skopje,R.Macedonia in the period from 2004-2014 year.Patients were at the age from 48-58 years(mean age 53years).Anamnesis and detailed neurological status was performed and neurophysiological(EEG,video EEG)and neuromorphological(MRI and CT-scan) investigations were also made.From neuropsychological tests:Minimental(MMSE) test,Ray Osterit complex figure(RKF) were made.
Results: Patiens with AD were diagnosed clinically and followed in the outpatient clinic.Six patients showed signs of parkinsonism:bradikynesia,rigidity,tremor and nonmotor symptoms(sleep disturbances,anxiety).From this, four patients had generalized tonic clonic(GTCS) epileptic seizures and two patients had motor automatisams.Patients with GTCS showed EEG changes and the other two showed paroxysms on video EEG.Patients with parkinsonism and epileptic seizures showed positive effect od antiepileptic therapy in a sence of decreased hyperexcitability of the brain and slowing of the disease progression.
Conclusions: In patient with AD and signs of parkinsonism epileptic seizures can occur and the same were diagnosed and treated.AET stoped the seizures and slowed the disease progression.
To cite this abstract in AMA style:I. Petrov. Parkinsonism in Patients with Alzheimer Disease and Epileptic Seizures [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/parkinsonism-in-patients-with-alzheimer-disease-and-epileptic-seizures/. Accessed December 11, 2023.
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