A homozygous loss-of-function mutation in DNAJA3 causes hereditary motor and sensory neuropathy with spastic paraplegia (HMSN type V)
Objective: To identify a genetic cause for hereditary motor and sensory neuropathy with spastic paraplegia (HMSN type V). Background: Hereditary spastic paraplegia (HSP) constitutes a…A phase 3, placebo-controlled study with an open-label extension: Sustained incobotulinumtoxinA efficacy in upper-limb post-stroke spasticity over 48 weeks
Objective: To assess the efficacy and safety of incobotulinumtoxinA for upper-limb post-stroke spasticity. Background: Botulinum toxin injections are a recommended therapy for limb spasticity. We…Safety and efficacy of escalating doses of incobotulinumtoxinA (400-800U): Increasing improvements in disability due to multifocal upper- and lower-limb spasticity
Objective: To assess the safety and efficacy of escalating incobotulinumtoxinA doses (400-800U) in patients with spasticity. Background: Botulinum toxin treatment at higher doses than currently…SPAsticity in PractiCE (SPACE) – An international, observational study of botulinum toxin type A in spasticity
Objective: To collect real-world routine clinical practice data on effectiveness, safety, and quality of life (QoL) for botulinum toxin type A (BoNT-A) treatment of focal…Muscle selection patterns for injection of onabotulinumtoxinA in adult patients with post-stroke lower-limb spasticity influence outcome: Results from a double-blind, placebo-controlled phase 3 clinical trial
Objective: The objective of this analysis is to identify an optimal muscle selection pattern for onabotulinumtoxinA injection for the treatment of post-stroke lower-limb spasticity (PSLLS).…Spastic gait and mechanical energy recovery in children with hereditary spastic paraplegia
Objective: We aimed to address spastic muscle behavior under dynamic conditions in children with hereditary spastic paraplegia (HSP). Background: HSPs are a clinically and genetically…Hemi-stereotypies symptomatic to aneurysm: Differential diagnosis of tardive dyskinesia
Objective: Below we present the case of a hemi-stereotypies symptomatic to aneurysm of the middle cerebral artery presented in mass effect on the subthalamic nucleus…A pilot study of SD-809 (deutetrabenazine) in tics associated with Tourette syndrome
Objective: This study explored the safety, tolerability and preliminary efficacy of SD-809 (deutetrabenazine) in adolescents with moderate to severe tics associated with Tourette syndrome (TS).…Longitudinal follow-up of the association of tic disorders with poor academic performance
Objective: To analyze whether the presence of a tic disorder is associated with an increased risk for developing poor academic performance overtime. Background: Tic disorders…The temporal relationship between premonitory sensations and tics compared to obsessions
Objective: Investigating the real-time relationship between premonitory urges and tics as compared to the urge to blink in healthy controls and the urge to execute…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.