Restless Limbs Syndrome (RLS) is More Likely a Premotor Symptom of Parkinson’s Disease then a Predisposing Condition.
Objective: A recent study suggested that 1.6% of RLS patients developed PD vs 1% of controls.The authors questioned whether RLS could be a premonitory symptom…Identifying Peripheral Stimulation Sites to Treat Parkinson’s Disease Gait Impairments
Objective: Our aim is to develop a non-invasive treatment for Parkinson’s Disease gait symptoms by applying peripheral stimulation to the feet using coordinated reset stimulation…Biomarker and Clinical Correlates of Restless Legs Syndrome (RLS) in Parkinson’s Disease: A Paradoxical Hyperdopaminergic State
Objective: To examine the clinical and biomarker correlates of Restless legs syndrome (RLS) in Parkinson’s disease (PD). Background: RLS is more common in PD than…Genomic Insights into Parkinson’s Disease: LARGE-PD and PD GENEration Collaboration in El Salvador
Objective: To characterize clinical and genetic features of Parkinson’s disease (PD) in El Salvador in the PD GENEration and LARGE-PD. Background: Central American populations remain…HD-RAC (Huntington’s Disease Research at Convention) Series: Novel approach to pilot data collection for outcome measures in Huntington’s disease
Objective: The aim of HD-RAC studies is to answer focused research questions or collect pilot data for use of digital health technology (DHT) in clinical…Objective Characteristics and Brain Network Alterations in Early-Stage Parkinson’s Disease with Gastric Motility Disorder
Objective: To characterize objective gastric motility disorder (GMD) in early-stage Parkinson’s disease (PD) and explore the underlying central neural network and structural alterations using multimodal…Progressive Dynamic Functional Network Disorganisation and its Association with Phenoconversion in Isolated REM Sleep Behaviour Disorder: A Multicentre Study
Objective: To characterise static and dynamic functional connectivity signatures of disease progression and phenoconversion in a multicentre longitudinal cohort of individuals with isolated REM sleep…Targeting the Immunoproteasome PSMB8: A dual strategy to enhance α-synuclein clearance and mitigate CD8+ T-Cell neurotoxicity in Parkinson’s Disease
Objective: To determine if the immunoproteasome (IP) subunit PSMB8 serves as a pathological link between α-synuclein aggregation and cytotoxic immune responses in Parkinson’s disease (PD).…Interplay of sex and GBA1 and LRRK2 genotype in Parkinson disease progression
Objective: To characterize disease heterogeneity and how sex impacts motor and cognitive progression class membership across genetic subgroups of GBA1, LRRK2, and idiopathic Parkinson disease (PD). Background: Autosomal…Towards Deep Learning for Personalized Parkinson’s Disease Tremor Segmentation and Severity Classification Using Wearable Sensors
Objective: The objective of this work is to develop and evaluate a deep learning framework for segmenting and classifying Parkinson’s disease (PD) resting tremor severity…
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