An International Consensus Framework for Computer Vision-ready acquisition and reporting: Toward Measurement-grade video in Neurology
Objective: To develop an international consensus framework for clinical video acquisition and metadata reporting optimized for Computer Vision-based movement analysis Background: Advances in Computer Vision (an AI method…Continued Evaluation of Clinical Outcomes in Participants With Parkinson’s Disease Through 4 Years After Bemdaneprocel Administration
Objective: To report safety and clinical outcomes in participants with Parkinson’s disease (PD), 4 years after receiving bemdaneprocel. Background: Bemdaneprocel is an investigational cell therapy…Chronic Vanadium Exposure Promotes Memory Impairment and Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain
Objective: In this study, we hypothesized that prolonged vanadium exposure may be a potential risk factor for Alzheimer's and Parkinson's diseases. Background: The interaction between…Sequential neurodegenerative trajectories across the onset of mild parkinsonian signs in isolated REM sleep behavior disorder: a longitudinal multimodal imaging study
Objective: To demonstrate the neurodegeneration status implied by mild parkinsonian signs (MPS) in patients with isolated REM sleep behavior disorder (iRBD) by analyzing longitudinal clinical…Clinicogenetic Characterization of Sporadic Adult-Onset Ataxias in Austria
Objective: To gain insight in the natural history of sporadic adult-onset ataxia (SAOA), identify unrecognized genetic underpinnings and improve early differentiation from other causes of…Volatile Organic Compound Signatures Differentiate Parkinson Disease from Parkinson Disease Mimic Syndromes and Controls
Objective: We aimed to isolate volatile organic compounds (VOCs) in cerumen and sebum samples from participants with Parkinson disease (PD), PD-mimic syndromes, Idiopathic REM Sleep…Young-Onset Parkinson’s Disease with Coexisting GBA1 Mutation and ATXN3 Repeat Expansion: A Double Hit?
Objective: To report a rare case of young-onset Parkinson’s disease (PD) with a positive family history in which the patient was found to harbor double…Bayesian Network Analysis of Directional Relationships Among Motor and Non-Motor Symptoms in Parkinson’s Disease
Objective: To identify directional relationships among motor and non-motor symptoms in people with Parkinson’s disease (PD) using Bayesian Network analysis and to identify central variables…Identification of Novel FA2H Mutations in Patients with Hereditary Spastic Paraplegia Type 35 (SPG35)
Objective: We reported three cases of SPG35 caused by compound heterozygous mutations in the FA2H gene, with ataxia as the initial clinical manifestation. Among the…Movement Disorder Phenotypes and Etiological Associations in Genetic Early-Onset Ataxias: A Pediatric Cohort Study
Objective: To investigate the frequency, clinical spectrum, and etiological correlates of movement disorders (MD) in early-onset ataxias. Background: Early-onset ataxias are rare genetic disorders (1).…
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