Identifying Differential DNA Methylation Pathways in Parkinson’s Disease and REM Sleep Behavior Disorder
Objective: To investigate differential methylation patterns of cell-free DNA (cfDNA) between Parkinson’s Disease (PD), REM Sleep Behavior Disorder (RBD), and Healthy Control (HC) groups. Background:…Therapeutic Effect and Mechanism of Targeted Nano-selenium in Mouse Model of Parkinson’s Disease Induced by MPTP
Objective: In the present study, we developed a nanozyme (Se@PB-ACPP) incorporating selenium-loaded Prussian blue (PB) and modified it with an activatable cell-penetrating peptide (ACPP) to…The feasibility and practical utility of virtual visits for patients with Parkinson’s disease in different World Regions
Objective: To compare the access and visit quality/acceptability between in-office and virtual telemedicine visits for patients with Parkinson' s disease (PD) Background: Overcoming existing access…Analysis of LRRK2 Exonic Variants in Parkinson’s Disease in Chinese Population
Objective: To investigate the frequency of multiple LRRK2 variants in Parkinson's disease (PD) cohort, and to explore the effect of LRRK2 variants on the occurrence…Investigating the Global Genetic Spectrum of Monogenic Parkinson’s Disease and Parkinsonism
Objective: To investigate known pathogenic and risk variants linked to Parkinson’s disease (PD) at a global, multi-ancestry scale. Background: Genetic forms of PD have been…Returning Secondary Health Findings in the PD GENEration study
Objective: To provide secondary health findings (SHF) results to participants enrolled in the PD GENEration study via CLIA genetic testing using whole genome sequencing (WGS)…A Case for Novel Phenotypes Associated with Digenic CHMP2B-LRRK2 Mutations
Objective: We report a patient presenting with both bv-FTD & PD phenotypes, alongside a complex family history featuring multiple neurodegenerative disorders. Background: The CHMP2B &…Familial parkinson disease A comparative study between LRRK2 and PINK 1 mutations
Objective: Describe the clinical phenotypes of monogenic forms of PD linked to LRRK2 and PINK1 mutations with a view to a comparative study between the…Linking Adolescent Brain Development To Parkinson’s Disease Risk Using Machine Learning On Polygenic Risk Scores
Objective: Examine whether adolescent brain structural deviations contribute to Parkinson’s disease (PD) susceptibility. Background: Genetic variants associated with PD have been linked to neurodevelopmental processes,…Disclosing CLIA certified genetic results within the LARGE-PD Cohort in Peru: Preliminary results of the PD GENEration study
Objective: To characterize the Peruvian Parkinson’s disease (PD) cohort within the Latin American Research Consortium on the GEnetics of Parkinson Disease (LARGE-PD) that received a…
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