From Cerebral Palsy to GNAO1-Related Movement Disorder: An Adult Diagnosis with Marked Response to Pallidal Deep Brain Stimulation
Objective: To report a case initially diagnosed as cerebral palsy, later identified as a GNAO1 gene–related movement disorder and to illustrate the therapeutic impact of…PD Similarity Index: A Wearable Gait Biomarker Capturing the Continuum from iRBD to Parkinson Disease
Objective: To evaluate a wearable IMU-derived PD Similarity Index (PSI), a continuous monotonic score designed to position individuals along the spectrum from healthy controls (HC)…Variants in Cytochrome P450–encoding Genes Associated with Parkinson’s Disease
Objective: To characterize the clinical features of PD associated with CYP gene variants (CYP‑iPD) and parkinsonism observed in other neurodegenerative diseases. Background: Cytochrome P450 (CYP)…Uncovering novel genomic alterations in dystonia using gene burden analysis
Objective: To identify genomic alterations that are over-represented in the Indian dystonia cohort using gene burden analysis of rare variants. Background: Dystonia is a complex…Outpatient Multidisciplinary Care for Parkinson’s Disease: A Narrative Review of Care Models and Outcomes
Objective: To summarize best practices in outpatient multidisciplinary care models for Parkinson’s disease (PD), focusing on team composition, care coordination, interventions, and patient-centered outcomes. Background:…Clinical features of vascular parkinsonism
Objective: To analyze the clinical, neurological, and anamnestic characteristics of patients with vascular parkinsonism. Background: Vascular parkinsonism (VP) remains a significant diagnostic challenge due to…Biomarker and Clinical Correlates of Restless Legs Syndrome (RLS) in Parkinson’s Disease: A Paradoxical Hyperdopaminergic State
Objective: To examine the clinical and biomarker correlates of Restless legs syndrome (RLS) in Parkinson’s disease (PD). Background: RLS is more common in PD than…Modulatory effects of bacterial-derived serine protease on pathological α-synuclein fibrillation in vitro
Objective: To investigate the modulatory effects of bacterial-derived proteins on the pathological aggregation of α-synuclein (α-syn) Background: Aggregation of α-syn into toxic oligomers and protofibrils…Discontinuation Patterns and Predictive Factors in Continuous Subcutaneous Foslevodopa/Foscarbidopa (FLC/FCD) Therapy: Insights from Early Clinical Experience
Objective: To characterize discontinuation patterns, reasons, and baseline predictors of therapy cessation in a prospective FLC/FCD cohort. Background: Real-world discontinuation rates for continuous subcutaneous FLD/FCD…Efficacy of Combining Outpatient Palliative Care with Standard Care on Quality of Life and Caregiver Burden in Atypical Parkinsonian Syndrome – A Randomised Controlled Trial
Objective: This study evaluates the effectiveness of structured outpatient palliative care combined with standard care compared to standard care alone at 3 and 6 months…
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