Hula as an Integrative Movement-Based Therapy: Baseline Cohort Characteristics
Objective: To describe baseline motor, non-motor, and psychosocial characteristics in a randomized, delayed-start hula intervention trial for Parkinson’s disease (PD). Background: Culturally grounded movement practices…Outcomes of Bilateral Deep Brain Stimulation Following Prior MR-guided Focused Ultrasound Thalamotomy
Objective: To evaluate the safety and efficacy of subsequent Deep Brain Stimulation (DBS) as a management strategy for patients with recurrent or residual symptoms following MR-guided Focused Ultrasound (MRgFUS) thalamotomy. Background: Despite its…The Burden of Cognitive Impairment in People with Parkinson’s across Outpatients and Prevalent Patients in Coastal Kenya: A Transforming Parkinson’s Care in Africa (TraPCAf) Study
Objective: To describe the rate and severity of cognitive impairment within the coastal Kenyan cohort of TraPCAf. Background: Cognitive impairment is a well-recognised non-motor symptom of PD, however there is very…Sex-Stratified Multi-Omic Integration Identifies Sexually Dimorphic Molecular Targets in Parkinson’s Disease
Objective: To identify sex-specific causal proteins and biological pathways underlying the sexual dimorphism of Parkinson's disease (PD) through an integrative multi-omics framework. Background: PD exhibits…Network determinants of stimulation-induced speech impairment after subthalamic DBS in Parkinson’s disease
Objective: To delineate hemisphere-specific, local, and network-level mechanisms underlying stimulation-induced speech impairment after subthalamic deep brain stimulation (STN-DBS). Background: STN-DBS can improve but also worsen…The Lived Experience of Parkinson’s Disease in the Philippines: Challenges, Cultural Constructs, and Caregiving Impacts
Objective: This study aims to explore the lived experiences of PD patients and their caregivers in Cebu Province, Philippines; identify psychosocial and healthcare-related challenges; assess…Modifiers of Intergenerational Repeat Changes in X-linked Dystonia–Parkinsonism
Objective: To investigate the effect of genetic modifiers of X-linked dystonia-parkinsonism (XDP) on the relevant repeat across generations. Background: XDP is a rare neurodegenerative disorder…Redefining Anatomical Boundaries, An Atypical Case of MV-PLUS with Supratentorial extension.
Objective: To report the first case of Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance (MV-PLUS) with atypical supratentorial temporal extension, expanding the known…Peripheral Inflammatory Markers and Clinical Correlations in Parkinson’s Disease Patients Carrying LRRK2 G2385R and R1628P Variants
Objective: To investigate plasma cytokines and chemokines with clinical correlations between Parkinson’s disease (PD) patients carrying LRRK2 p.G2385R and/or p.R1628P variants, idiopathic PD (iPD), and healthy controls.…Evaluation of Sleep Parameters in Parkinson’s Disease According to Disease Duration Using Ambulatory Circadian Monitoring
Objective: To evaluate clinical characteristics and objective sleep parameters in patients with Parkinson’s disease (PD) according to disease duration (<6 years versus >6 years). Background: Sleep disturbances are…
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