Clinical and Functional Outcomes of Antiviral and Immunomodulatory Therapies in Subacute Sclerosing Panencephalitis
Objective: To evaluate whether antiviral and immunomodulatory treatments meaningfully improve true functional status and disease stabilization, or if they merely prolong survival in a state…Adult hippocampal neurogenesis and cognitive and neuropsychiatric symptoms in Parkinson’s disease: the MemHiN study
Objective: To examine associations between serum-derived adult hippocampal neurogenesis (AHN)1 markers and cognitive and neuropsychiatric symptoms in Parkinson’s disease (PD), and to explore whether a…Transcriptomic Profiling of Frataxin-Deficient Drosophila melanogaster to Identify Molecular Drivers and Pathway Disruptions in Friedreich’s Ataxia
Objective: To characterize the global transcriptomic changes and molecular pathways disrupted by frataxin deficiency in a Drosophila model of Friedreich's Ataxia (FA) to identify potential…Psychosis in Parkinson’s Disease Patients Treated with Continuous Subcutaneous Foslevodopa/Foscarbidopa: A Real-World Observational Study.
Objective: To assess the incidence and timing of psychosis (hallucinations and delusions) in Parkinson’s disease patients receiving continuous subcutaneous infusion of foslevodopa/foscarbidopa (CSFLI). Background: CSFLI…Triplet repeat length determines the liquid-liquid phase separation propensity of single-dtranded DNA
Objective: To determine whether CAG trinucleotide repeat number intrinsically governs liquid-liquid phase separation (LLPS) of single-stranded DNA (ssDNA). Background: LLPS has emerged as a fundamental…Simulation Artifact in Complex Deep Brain Stimulation Patients
Objective: To describe stimulation artifacts in patients with complex deep brain stimulation hardware configurations and the impact on electrophysiology recordings. Background: Deep brain stimulation (DBS)…Low-dose ketamine reduces dopamine 2 receptor-like agonist-induced dyskinesia in a preclinical model
Objective: Preclinical evaluation of low-dose ketamine treatment on dyskinesia induced by direct or indirect striatofugal pathway activation. Background: Ketamine infusions are effective therapy for depression…The Burden of Cognitive Impairment in People with Parkinson’s across Outpatients and Prevalent Patients in Coastal Kenya: A Transforming Parkinson’s Care in Africa (TraPCAf) Study
Objective: To describe the rate and severity of cognitive impairment within the coastal Kenyan cohort of TraPCAf. Background: Cognitive impairment is a well-recognised non-motor symptom of PD, however there is very…Self-Efficacy in Lewy Body Dementia Family Caregivers Is Associated with Better Sleep Quality and Social Support, and Lower Depression, Loneliness, and Strain
Objective: Examine the association of perceived self-efficacy in symptom management and community support service use with physical, psychological, and social well-being of Lewy Body Dementia…Efficacy of Repetitive Transcranial Magnetic Stimulation for Improving Motor Function in Parkinson’s disease; A Prospective, Multicenter, Crossover Study
Objective: We aimed to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the improvement of motor function in patients with Parkinson’s disease (PD).…
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