Clinical Features and Treatment Response in Stiff Person Spectrum Disorder: A Case Series from a Tertiary Neurology Centre
Objective: To describe the clinical features, electrophysiological findings, and treatment outcomes of patients with Stiff Person Spectrum Disorder (SPSD) evaluated at a tertiary neurology centre.…Accelerated brain iron accumulation secondary to hypoxia in a patient with hereditary haemochromatosis with homozygous C282Y mutations.
Objective: To describe the case of a 60-year-old male with a diagnosis of Hereditary Haemochromatosis (HHE) with homozygous C282Y mutations presenting with progressive parkinsonism, cognitive…Levodopa-Induced Dyskinesias in Patients with Parkinson’s Disease in the Uzbek Population
Objective: To investigate the clinical features and prevalence of levodopa-induced dyskinesias in patients with Parkinson’s disease in the Uzbek population. Background: Levodopa-induced dyskinesias (LID) are…Global Performance Patterns in the MDS-UPDRS Motor Certification Program: A five-year Analysis
Objective: To evaluate participation trends, certification rates, case-level difficulty, and item-level performance patterns over five years. Background: The MDS-UPDRS Part III is a core outcome…The Prevalence of Parkinson’s Disease in Kilifi County, Kenya: A ‘Transforming Parkinson’s Care in Africa’ (TraPCAf) study
Objective: We aimed to determine the prevalence of PD in Kilifi County, Kenya within the Kilifi Health and Demographic Surveillance System and evaluate the performance…Feasibility study of a portable medical device, the Neuromotor pen, as a screening tool for Parkinson’s disease in a rural northern Tanzania
Objective: To evaluate the feasibility and acceptability of the Neuromotor pen (NMP) as a screening tool for Parkinson’s disease in a rural Tanzanian population. Background:…Dopaminergic reconfiguration of an inverted network hierarchy in Parkinson’s disease
Objective: To determine how acute dopaminergic treatment reshapes large-scale brain network organization in Parkinson’s disease (PD). Background: Dopamine replacement reliably improves motor symptoms in PD,…Reconfiguration of Structural-Functional Coupling Associated with Clinical Features and 5-Year Progression in Parkinson’s Disease: A Cross-sectional and Longitudinal Study
Objective: This study aimed to characterize Structural–functional coupling (SFC) reorganization in Parkinson’s disease (PD), examine its associations with motor and cognitive performance, and assess whether…Study on the Mechanism of SIRT3 Protecting Parkinson’s disease by Regulating Mitophagy
Objective: To clarify the protective effect of SIRT3 on Parkinson's disease (PD) and the molecular mechanism by which it regulates mitophagy. Background: PD involves movement…Peripheral Inflammatory Markers and Clinical Correlations in Parkinson’s Disease Patients Carrying LRRK2 G2385R and R1628P Variants
Objective: To investigate plasma cytokines and chemokines with clinical correlations between Parkinson’s disease (PD) patients carrying LRRK2 p.G2385R and/or p.R1628P variants, idiopathic PD (iPD), and healthy controls.…
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