Neuropsychiatric Symptoms in Lewy Body Disease: Monoaminergic Activity and Resting State Networks
Objective: Investigating how neuropsychiatric symptoms (NPS)—depression, anxiety, and apathy—relate to functional connectivity between monoaminergic nuclei and the limbic network (LN), default mode network (DMN), and…Parkinson’s Disease Early Diagnostic and Prognostic Biomarkers Identified by Large-scale Plasma and Cerebrospinal Fluid Proteomic Profiling
Objective: To identify reliable diagnostic and prognostic protein biomarkers for early-stage Parkinson’s disease (PD) using large-scale proteomic profiling of plasma and cerebrospinal fluid (CSF).To identify…Comprehensive Diagnostic Accuracy of α-Synuclein Seed Amplification Assays Across Non-Parkinsonian Synucleinopathies: A Systematic Review and Diagnostic Meta-analysis
Objective: To evaluate the diagnostic accuracy of αSyn-SAAs across established and prodromal non-Parkinsonian synucleinopathies, including Lewy body disorders (DLB), multiple system atrophy (MSA), isolated REM…Evaluating Parkinson’s Disease Telehealth in Residential Aged Care
Objective: To evaluate the use, barriers, outcomes, and clinician perspectives of specialist telehealth for Parkinson’s disease (PD) care in residential aged care facilities. Background: Specialist…Beta and Gamma Local Field Potentials in Chronic Deep Brain Stimulation for Parkinson’s Disease: Programming Implications from a Systematic Review
Objective: To define distinct clinical roles of beta- and gamma-band local field potential (LFP) biomarkers in chronic deep brain stimulation (DBS) for Parkinson’s disease (PD)…Diagnostic Utility of Routine 1.5T Brainstem Planimetry in Parkinsonism: Evidence from a Vietnamese Cohort
Objective: To compare absolute versus ratio brainstem planimetric measures on routine 1.5T MRI and to identify the best-performing metrics for differentiating PSP and MSA in…Irisin as a Molecular Mediator of Exercise Induced Neuroprotection and Disease Modification in Parkinson’s Disease
Objective: To integrate mechanistic evidence delineating irisin mediated molecular pathways relevant to Parkinson’s disease (PD) pathogenesis and neuroprotection, focusing on α-syn clearance, autophagy–lysosomal function, mitochondrial…Evaluation of Swallowing and Cough Function in older Patients with Parkinson’s Disease
Objective: This study aimed to characterize swallowing and cough function in older patients with Parkinson’s disease (PD) using a multidimensional assessment. Background: With population aging,…Chronic Vanadium Exposure Promotes Memory Impairment and Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain
Objective: In this study, we hypothesized that prolonged vanadium exposure may be a potential risk factor for Alzheimer's and Parkinson's diseases. Background: The interaction between…The GLP-1 Agonist Paradox in Parkinson’s Disease: A Comparative Analysis of Lixisenatide and Exenatide Phase III Trial Outcomes and Neuroprotective Mechanisms
Objective: To assess the pharmacological and methodological factors underlying the "GLP-1 paradox" by comparing the outcomes of lixisenatide and exenatide, with an emphasis on kinetics,…
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