Efficacy of Vitamin C for Restless Legs Syndrome: A Systematic Review and Meta‑analysis of Randomized Controlled Trials
Objective: To evaluate the efficacy and safety of vitamin C (VITC) for treating restless legs syndrome (RLS) using evidence exclusively from randomized controlled trials (RCTs).…Evaluation of Swallowing and Cough Function in older Patients with Parkinson’s Disease
Objective: This study aimed to characterize swallowing and cough function in older patients with Parkinson’s disease (PD) using a multidimensional assessment. Background: With population aging,…Chronic Vanadium Exposure Promotes Memory Impairment and Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain
Objective: In this study, we hypothesized that prolonged vanadium exposure may be a potential risk factor for Alzheimer's and Parkinson's diseases. Background: The interaction between…The GLP-1 Agonist Paradox in Parkinson’s Disease: A Comparative Analysis of Lixisenatide and Exenatide Phase III Trial Outcomes and Neuroprotective Mechanisms
Objective: To assess the pharmacological and methodological factors underlying the "GLP-1 paradox" by comparing the outcomes of lixisenatide and exenatide, with an emphasis on kinetics,…Cognitive Progression in Elderly Essential Tremor Patients: Evidence from an 18-Month Prospective Cohort
Objective: Essential tremor (ET) is one of the most prevalent neurological disorders and has increasingly been linked to cognitive dysfunction. However, most existing data regarding…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Rare Neurotoxicity of Cotrimoxazole A Movement Disorder Presentation In Elderly Patient
Objective: We report the case of an elderly woman with hyperkinetic movement disorders Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used for Pneumocystis jirovecii prophylaxis, but significant neurological toxicity…Clinical Characteristics and Functional Impact of Tremor in Patients with Multiple Sclerosis in Nepal: A Cross-Sectional Observational Study
Objective: To describe the clinical characteristics of tremor in multiple sclerosis (MS) patients in Nepal and assess its functional impact on daily living. To describe…Antidepressants in Huntington’s Disease: A Meta Analysis of Mood and Motor Outcomes with Placebo-controlled Trials
Objective: To evaluate the efficacy of antidepressants for depression in Huntington’s disease (HD). Background: Depression is highly prevalent in HD. Despite frequent clinical use of…Dynamics of Motor Fluctuations and Medication Challenges in Parkinson’s Disease
Objective: To investigate the dynamics of tremor, bradykinesia, and finger dexterity during the OFF-to-ON transition using objective measures. Additionally, assesses medication administration challenges through a…
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