THD (Tyrosine Hydroxylase Deficiency) in a 39-Year-Old Woman with Early-Onset Dystonia
Objective: To report a case of tyrosine hydroxylase deficiency (THD), a rare neurometabolic disorder that disrupts catecholamine biosynthesis. This case report highlights common neurologic abnormalities,…Comparative efficacy and safety of Safinamide versus Opicapone in Japanese patients with Parkinson’s Disease and wearing-off: A matching-adjusted indirect comparison
Objective: To compare efficacy and safety outcomes with safinamide and opicapone as adjuncts to levodopa in Parkinson’s disease (PD) patients with wearing-off using an anchored…Iron-independent initiation of neurodegeneration in BPAN
Objective: Beta-propeller protein–associated neurodegeneration (BPAN) is caused by mutations in WDR45 and classified within the neurodegeneration with brain iron accumulation (NBIA) spectrum. Although brain iron…Diagnostic Utility of [18F]FDG-PET in the Differential Diagnosis of Parkinsonian Syndromes: A Retrospective Study in an Indian Tertiary Care Cohort
Objective: To evaluate the diagnostic utility of FDG-PET imaging for differentiating Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal syndrome…Real-World Impact of “Off” Time Reduction with Foslevodopa/Foscarbidopa in Advanced Parkinson’s Disease: Post Hoc Analysis of the ROSSINI Study
Objective: Examine dyskinesia and quality of life (QoL) outcomes in patients experiencing meaningful clinical improvements in “off” time during treatment with foslevodopa/foscarbidopa (LDp/CDp). Background: Clinical…Clinical Profile and Key Correlates of Genetic Load, Motor Severity, and Caregiver Burden in an Iranian Huntington’s Disease Cohort
Objective: To characterize an Iranian Huntington’s disease (HD) cohort and quantify associations between CAG repeat length, age at onset, motor severity, and caregiver burden. Background:…Diagnostic Accuracy of NPH by Radiographic Suspicion and Effect on Patient Outcomes
Objective: Our study examines the radiographic accuracy when suggesting normal pressure hydrocephalus (NPH), correlation with imaging study indication, and frequency of lumbar puncture (LP) for…Tongue Fasciculations in Amyotrophic Lateral Sclerosis Compared Between Electromyography and Transoral Ultrasonography
Objective: To compare the detection of tongue fasciculations between electromyography (EMG) and transoral motion-mode ultrasonography (TOMU) in patients with amyotrophic lateral sclerosis (ALS), and to…Oral D1-like/D2-like Receptor Agonist, Lu AF28996, Provides Robust Antiparkinsonian Efficacy with Reduced Dyskinesia in the MPTP-Macaque Model
Objective: Evaluate the therapeutic potential of Lu AF28996 in the MPTP-macaque model of PD. Background: Chronic levodopa treatment is associated with the development of motor…Parkinson’s Disease Early Diagnostic and Prognostic Biomarkers Identified by Large-scale Plasma and Cerebrospinal Fluid Proteomic Profiling
Objective: To identify reliable diagnostic and prognostic protein biomarkers for early-stage Parkinson’s disease (PD) using large-scale proteomic profiling of plasma and cerebrospinal fluid (CSF).To identify…
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