Non-Motor Symptom Improvement as a Driver of Quality of Life after Subthalamic Stimulation in Symmetric Parkinson’s Disease
Objective: To investigate non-motor outcomes in patients with symmetric vs. asymmetric motor symptoms following subthalamic stimulation (STN-DBS) in Parkinson’s disease (PD). Background: Motor asymmetry is…Behavioral Phenotype of a Mouse Model of Mixed Movement Disorders Linked to ADCY5
Objective: To define the motor and non-motor phenotypic features of a novel Adcy5R419W mouse line [1] and validate it as an integrated model of human mixed movement disorders…Cognitive Profile In Indian Patients with Spinocerebellar Ataxia (SCA) – Prospective Cross-sectional Study
Objective: To evaluate the prevalence, spectrum, and severity of cognitive impairment in Indian patients with genetically confirmed SCA and corelate with motor severity. Background: Beyond…Pattern and progression of sudomotor dysfunction in alpha synucleinopathies
Objective: This study examined the distribution and longitudinal progression of sweat loss in patients with PAF. Background: Pure autonomic failure (PAF) is an alpha-synucleinopathy with…Rare Variant Analysis in Parkinson’s Disease Patients Stratified by Polygenic Risk
Objective: To identify rare variants that may contribute to Parkinson’s disease (PD) risk in individuals whose polygenic background does not adequately explain their disease status.…Parkinsonism Revealing a Late Form of Niemann-Pick Disease About a Case
Objective: Niemann-Pick type B (NPB) is a rare, autosomal dominant hereditary disorder. Clinical presentation is primarily visceral. Neurological manifestations are rare, unlike in other types…Dynamics of Motor Fluctuations and Medication Challenges in Parkinson’s Disease
Objective: To investigate the dynamics of tremor, bradykinesia, and finger dexterity during the OFF-to-ON transition using objective measures. Additionally, assesses medication administration challenges through a…Rare Heterozygous SLC25A12 Variants Are Associated with Parkinson’s Disease
Objective: To identify rare genetic variants contributing to Parkinson’s disease (PD) using analysis of multiplex families and large-scale genomic datasets. Background: Rare variants identified through…Assessment of α-Synuclein Seeding Activity in the Olfactory Mucosa after SARS-CoV-2: a Pilot Study
Objective: To determine whether symptomatic SARS-CoV-2 infection is associated with local α-synuclein (aSyn) aggregation in the olfactory mucosa (OM) as measured by an aSyn seeding…Digital Health, Telemedicine, and Artificial Intelligence in Parkinson’s Disease Management During COVID-19: A Narrative Review
Objective: The objective of this narrative review was to evaluate the effectiveness of telemedicine and AI-based technologies used for the remote monitoring and management of…
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