Diagnosis and therapeutic approaches for sialorrhea in patients with Parkinson’s disease.
Objective: To study the frequency of drooling complaints in Parkinson's disease (PD) patients during outpatient visits. Background: Sialorrhea (excessive drooling) is a non-motor symptom of…Assessment of α-Synuclein Seeding Activity in the Olfactory Mucosa after SARS-CoV-2: a Pilot Study
Objective: To determine whether symptomatic SARS-CoV-2 infection is associated with local α-synuclein (aSyn) aggregation in the olfactory mucosa (OM) as measured by an aSyn seeding…Multi-tracer positron emission tomography reveals early disruption of cerebrospinal fluid clearance in Huntington’s disease
Objective: To evaluate lateral ventricular (LV) positron emission tomography (PET) signal and choroid plexus (CP) volume as biomarkers of disease progression in Huntington’s disease (HD),…Assessing Agreement of Self-Perception of Dysphagia in Individuals with Parkinson Disease and their Caregivers
Objective: To investigate the association of self-perception of dysphagia in individuals with Parkinson disease (IwPD) with their caregivers’ perceptions at early, mid and late stages…Association of Glymphatic Flow at Diffusion Tensor Image with Motor Symptoms and Striatal Dopamine Degeneration in Parkinson’s Disease
Objective: This study aimed to investigate the association between the diffusion tensor image (DTI) analysis along the perivascular space (ALPS) index, dopamine transporter (DAT) availability…Suicidal Ideation and the Hippocampal Histaminergic System in Huntington’s Disease: A PET Study
Objective: To determine whether presence and severity of suicidal ideation (SI) are associated with hippocampal volume and histamine H3 receptor (H3R) PET uptake in people with Huntington’s disease (PwHD). Background: Suicidal ideation occurs in approximately 8–27% of PwHD, yet its causes remain unclear(1–3). The…Changes in Continuous Good ON and Best ON Time During the Waking Day With Tavapadon in People With Parkinson’s Disease
Objective: To evaluate motor states throughout the waking day when tavapadon is added to oral carbidopa/levodopa in adults with Parkinson’s disease (PD) experiencing motor fluctuations.…Diagnostic Utility of [18F]FDG-PET in the Differential Diagnosis of Parkinsonian Syndromes: A Retrospective Study in an Indian Tertiary Care Cohort
Objective: To evaluate the diagnostic utility of FDG-PET imaging for differentiating Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal syndrome…Comparative Efficacy of Wrist-Worn Non-Invasive Peripheral Nerve Stimulation for Essential Tremor: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Objective: We aimed to evaluate the efficacy of non-invasive peripheral nerve stimulation (PNS) in reducing clinician-rated tremor severity in essential tremor, assess its effects on…Feasibility and Preliminary Outcomes of an Online Fatigue Self Management Programme for People With Parkinsons Disease
Objective: To assess the feasibility, acceptability, and preliminary outcomes of an online fatigue self management programme for people with Parkinsons disease. Background: Fatigue is a…
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