Beyond α-Synuclein SAA: A Multimodal Minimally Invasive Platform for Biologically Informed Diagnosis of Parkinsonian Syndromes
Objective: To evaluate whether integrating dermal α-synuclein and 4R-tau seed amplification assays (SAAs) with serum neurofilament light chain (NfL) improves diagnostic precision in neurodegenerative parkinsonian…Integrating Transcriptomics and Morphological Profiling to Characterize GBA-Associated Parkinson’s Disease in Midbrain Organoids
Objective: This study characterizes converging biological trends in GBA-associated Parkinson’s Disease by integrating transcriptomic profiling with exploratory image-based analysis of donor-matched midbrain organoids. Background: High-content…Does Unilateral MR-Guided Focused Ultrasound Subthalamotomy Provide Bilateral Motor Benefit in Parkinson Disease
Objective: To evaluate the effect of unilateral STN-MRgFUS on ipsilateral motor symptoms at 6 and 12 months post-procedure. Background: In patients with Parkinson’s disease (PD)…Cannabis-based Oil for Pain and Other Non-motor Symptoms in Parkinson’s Disease: a Randomized Controlled Trial
Objective: To assess the safety, tolerance, and effectiveness of an oil extract of Cannabis sativa L. on pain and other non-motor symptoms (NMS) in people…Epidemiology of Parkinson’s Disease and Parkinsonism in Kazakhstan from 2015 to 2024 based on National Health Data
Objective: To evaluate the prevalence and dynamics of Parkinson’s disease and parkinsonian syndromes in the population of Kazakhstan from 2015 to 2024 using data from…Progressive Lifelong Chorea with Spastic Paraparese and Cerebellar Ataxia Associated with Two Heterozygous Variants in the SYNE1 Gene: A Case Report
Objective: To report a case harboring two different heterozygousSYNE1 variants whose combined effect is suspected tounderlie a complex neurogenetic phenotype Background: SYNE1 encodes nesprin-1, one…The Impact of Demographic Factors on Skull Density Ratios in a Hawaii Cohort
Objective: To understand the impact of demographic factors on skull density ratio (SDR) in Hawai‘i patients. Background: SDR is a validated indicator of the ability…Robot-Assisted Transplantation of Hypoimmune iPSC Derived Dopaminergic Progenitor Cells for Idiopathic Parkinson’s Disease
Objective: This study aimed to evaluate the 12-month safety and preliminary efficacy of NCR201 transplantation in idiopathic PD patients, providing a proof-of-concept for universal cell…Anti-IgLON5 Encephalitis Presenting as Chronic Progressive Asymmetrical Ataxia and Chorea
Objective: To report a case of gait instability and progressive asymmetrical chorea clinically confirmed as anti-IgLON5 encephalitis. Background: Anti-IgLON5 encephalitis is a rare autoimmune neurological…Pharmacogenomic Analysis of KM-819-Related Hepatotoxicity in Patients with Multiple System Atrophy
Objective: This study aimed to identify genetic risk factors linked to a drug candidate for MSA (KM-819)-associated drug-induced liver injury (DILI) in patients with multiple…
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