Continuous subcutaneous levodopa/carbidopa infusion with ND0612 for Parkinson’s disease: Three-year data from the open-label BeyoND study
Objective: To evaluate three-year outcomes from the ND0612 BeyoND study. Background: Investigational ND0612 is in development as a 24-hour continuous, subcutaneous infusion of liquid levodopa/carbidopa…Neuropsychological and quality of life outcome comparison after awake and asleep pallidal deep brain stimulation (DBS) surgery for Parkinson’s disease
Objective: To compare cognitive, psychiatric and quality of life (QoL) outcomes after awake and asleep bilateral pallidal (GPi) deep brain stimulation (DBS). Background: Prior studies…IncobotulinumtoxinA to treat sialorrhea in Parkinson’s disease: a real-life study: 4-year interim results
Objective: We evaluate the long-term efficacy and safety of incobotulinumtoxinA injections in advanced Parkinson’s disease (PD) patients suffering from sialorrhea. Background: Sialorrhea is frequently a…Innovating Clinical Trial Design to Accelerate Assessment of Disease-Modifying Treatments for Parkinson’s: The EJS ACT-PD Initiative
Objective: To design an optimal multi-arm, multi-stage (MAMS) platform trial for disease-modifying therapies (DMTs) in Parkinson’s disease (PD). Background: The current clinical trials process cannot…Exploring mitochondrial mechanisms defining Parkinson’s disease penetrance in LRRK2 G2019S neuronal cultures
Objective: We explored mitochondria as integrators of genetics and environment in LRRK2 G2019S neuronal models. Specifically, we aimed to unravel mitochondrial mechanisms that define the…Education level and the onset and severity of symptoms in Huntington’s disease
Objective: The current study aimed to investigate the effect of educational level on the clinical characteristics of Chinese patients with Huntington’s disease (HD). Background: Education…TREM2 maintain microglial proliferation and α-syn accumulation in PD models via the PI3K-Akt pathway
Objective: To investigate the effect and role of TREM2 in microglial proliferation, α-syn-associated pathology and dopaminergic degeneration in Parkinson’s disease (PD). Background: PD is characterised…Cortical excitability of sensorimotor cortex in Parkinson’s disease-related pain
Objective: To clarify the functional role of sensorimotor cortex in Parkinson’s disease (PD)-related pain. Background: Pain is one of the most common nonmotor symptoms in…Contactless assessment of rigidity in Parkinson’s disease using machine vision and machine learning
Objective: To develop a contactless assessment model for rigidity evaluation in Parkinson’s Disease (PD) Background: Rigidity in PD is evaluated manually in current practice, and examiners need…Initial triggering in tibial group and subsequent slow spread of myoclonus from brain stem to eye-balls in Subacute Sclerosing Pan Encephalitis
Objective: To report spread of myoclonus in Subacute Sclerosing Pan Encephalitis (SSPE) Background: SSPE is a slowly progressive encephalitis caused by mutant measles virus with…
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