Basal Ganglia Germinoma (BGG) Presenting as Hemidystonia
Objective: We describe an unusual case of progressive right-sided hemidystonia with accompanying imaging and video. Background: Intracranial germinomas most often arise from midline structures, but…Smell as a Diagnostic Signature: Systematic Review and Meta-Analysis of UPSIT Accuracy in Distinguishing Parkinson’s Disease from Essential Tremor
Objective: To evaluate the diagnostic performance of the University of Pennsylvania Smell Identification Test (UPSIT) in differentiating Parkinson’s disease (PD) from essential tremor (ET) using…Evaluating Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 as Radiographic Metrics to Differentiate Progressive Supranuclear Palsy (PSP) from Normal Pressure Hydrocephalus (NPH)
Objective: We analyze the discriminatory diagnostic value of the Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 in progressive supranuclear palsy (PSP) and normal pressure…Anti-IgLON5 Encephalitis Presenting as Chronic Progressive Asymmetrical Ataxia and Chorea
Objective: To report a case of gait instability and progressive asymmetrical chorea clinically confirmed as anti-IgLON5 encephalitis. Background: Anti-IgLON5 encephalitis is a rare autoimmune neurological…Demystifying the Delivery of Multi-arm Multi-stage Platform Trials for Parkinson’s Disease –Framework and Recommendations from EJS ACT-PD
Objective: To develop a framework of protocol-aligned rater training, educational resources, and inter-site engagement (Stage 1). The secondary aim was to assess the perceived usefulness…Investigating Phospho-α-Synuclein Pathology in Patient-Specific Microglia Integrated into Midbrain Organoids
Objective: This study aims to determine how patient-specific microglia influence phospho-α‑synuclein aggregation and contribute to disease-relevant phenotypes within human midbrain organoids. Background: Parkinson’s disease (PD)…Gut Barrier Failure In Parkinson Disease: Reduced Colonic Resilience In Moderate Disease And Spontaneous Pan-Intestinal Leak In Severe Disease
Objective: To determine whether intestinal barrier dysfunction in Parkinson disease (PD) is stage-specific by assessing baseline epithelial permeability and resilience to inflammatory and microbial stressors.…Holistic Sensor-Based Profiling of Parkinson’s Disease via Mixed Reality: Implementation and Multimodal Feasibility
Objective: To validate a novel multimodal mixed-reality (MR) platform utilizing HoloLens 2 for the automated assessment of Parkinson’s disease (PD) symptoms and to determine the…Machine Learning–Based Brain Age Modeling Reveals Accelerated Structural Degeneration in Parkinson’s Disease
Objective: To compare the rate of global brain structural degeneration between healthy controls (HC) and patients with Parkinson’s disease (PD). Background: Normal aging is accompanied…Pain relief beyond motor cortex modulation: clinical–neurophysiological dissociation after M1-tDCS in Parkinson’s disease
Objective: To analyze the correlation between changes in pain-related outcomes and neurophysiological cortical measures following transcranial direct current stimulation (tDCS) in Parkinson’s disease (PD). Background:…
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