Presence of Common Psychiatric Diagnoses Did Not Impact the Efficacy or Safety of Ecopipam in Individuals With Tourette Syndrome
Objective: To evaluate ecopipam efficacy/safety in individuals with Tourette syndrome (TS) with or without common psychiatric comorbidities. Background: Co-occurring psychiatric conditions are frequently observed with…Comorbid Diabetes Exacerbates Motor and Nonmotor Dysfunction in Parkinson’s disease- a Cross-sectional Study
Objective: To compare the severity of motor and nonmotor manifestations of Parkinson’s disease (PD) in Indian patients with and without comorbid Type 2 Diabetes Mellitus…Machine Learning–Based Brain Age Modeling Reveals Accelerated Structural Degeneration in Parkinson’s Disease
Objective: To compare the rate of global brain structural degeneration between healthy controls (HC) and patients with Parkinson’s disease (PD). Background: Normal aging is accompanied…A Distinct Genetic Landscape of Progressive Supranuclear Palsy in Asians: Beyond the MAPT-Dominant Paradigm
Objective: To delineate the genetic architecture of progressive supranuclear palsy (PSP) in a large, multicenter, multinational Asian cohort using whole-exome sequencing (WES) and investigate the…Video-Nystagmographic Biomarkers of Oculomotor Dysfunction in Parkinson’s Disease: Correlation With Motor Severity and Cognition
Objective: To quantitatively evaluate oculomotor dysfunction using video-nystagmography (VNG) in patients with Parkinson’s disease (PD) and determine its association with motor severity, disease duration, and…Complete Resolution of Troublesome Dyskinesia in People With Advanced Parkinson’s Disease Treated With Foslevodopa/Foscarbidopa: Post Hoc Analysis From a 52-Week Phase 3 Trial
Objective: To evaluate the achievement of complete elimination of troublesome dyskinesia (TSD) and associated changes in Off time, motor aspects of experiences of daily living…Risk stratification study of fluid biomarkers for alpha-synucleinopathy with dementia
Objective: This study focuses on mixed pathology of α-synucleinopathy and Alzheimer’s disease(AD), analyzing the relationships among biomarkers, genetic factors, and cognitive function in order to…Extended long-term follow-up of adaptive deep brain stimulation in Parkinson’s disease
Objective: To evaluate the extended long-term durability, programming stability, and safety of adaptive deep brain stimulation (aDBS) in people with Parkinson’s disease (PD). Background: Adaptive DBS is a recently available enhancement to continuous DBS (cDBS) that dynamically adjusts stimulation amplitude based on neural…Safety and Effect of Ecopipam During the First 8 Weeks of Treatment for Tourette Syndrome: A Post Hoc Analysis
Objective: To assess the safety profile and effect of ecopipam, a selective dopamine D1 receptor antagonist, during the first 8 weeks of therapy for Tourette…Video-Based Gait Analysis for Objective Assessment of Motor Severity and Surgical Outcome in Parkinson’s Disease: A Scalable Alternative to Subjective Rating
Objective: To evaluate the accuracy of a gait-focused video analysis model in predicting clinical scores and post-surgical improvement in Parkinson’s disease (PD) Background: The MDS-UPDRS…
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