DDX17 Drives Astrocytic Mitochondrial Metabolic Reprogramming and Contributes to Parkinson’s Disease Progression
Objective: To investigate whether DDX17, an RNA helicase identified as a Parkinson's disease (PD) risk gene, regulates astrocytic mitochondrial metabolism and contributes to dopaminergic neuron…Gut Barrier Failure In Parkinson Disease: Reduced Colonic Resilience In Moderate Disease And Spontaneous Pan-Intestinal Leak In Severe Disease
Objective: To determine whether intestinal barrier dysfunction in Parkinson disease (PD) is stage-specific by assessing baseline epithelial permeability and resilience to inflammatory and microbial stressors.…Beyond Movement Amplitude: Interaction‑ and Asymmetry‑Aware Facial Blendshape Analysis in Parkinsonian Hypomimia
Objective: To quantify parkinsonian hypomimia beyond movement amplitude using a smartphone-based facial blendshape system incorporating interaction and asymmetry features. Background: Hypomimia is an early motor…Association Between Sleep Disturbance and Fatigue in Patients with Parkinson’s Disease
Objective: This study aimed to comprehensively investigate the associations between sleep disturbance and several non-motor symptoms, with a particular focus on the relationship with fatigue.…Monocyte and T-cell Immunological Profiles of Asian LRRK2 Variants G2385R And R1628P in Parkinson’s Disease: Associations with Clinical Measures
Objective: To evaluate the clinical correlates of monocyte and T-cell immunoprofiles in Parkinson’s disease (PD) with and without Asian LRRK2 variants. Background: Immune dysregulation has…Genetic Variation in KCNJ6 Gene Increases Risk of Impulse Disorders in Parkinson’s Disease: A Two-Cohort Study
Objective: To investigate the association between polymorphisms related to reward and punishment processing, and the development of impulse control disorders (ICDs) and compulsive behaviors (CBs)…Behavioral Phenotype of a Mouse Model of Mixed Movement Disorders Linked to ADCY5
Objective: To define the motor and non-motor phenotypic features of a novel Adcy5R419W mouse line [1] and validate it as an integrated model of human mixed movement disorders…Predictors of Shunt Placement for Patients with Normal Pressure Hydrocephalus following a Multidisciplinary Evaluation
Objective: Measures of cognition and gait pre- and post-lumbar puncture (LP) may predict which patients with concern for normal pressure hydrocephalus (NPH) are better candidates…Evaluation of Semantic Space Search Metrics in Phonemic Fluency: Comparison among Basal Ganglia Disorders and Healthy Controls
Objective: Phonemic verbal fluency reflects executive function and involves both within-category lexical retrieval (cluster size) and switching between categories. We compared semantic search behavior in…Seed Amplification Assay Is More Sensitive To Detecting α-Synuclein In Gut Biopsies Than Immunohistochemistry
Objective: Assess seed amplification assay (SAA) and immunohistochemistry (IHC) in peripheral gut mucosal biospecimens as PD diagnostics. Background: SAA detects misfolded alpha-synuclein (α-syn) aggregates across…
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