Early onset of efficacy during titration in US phase 3 open-label InfusON trial of apomorphine subcutaneous infusion for Parkinson’s disease motor fluctuations
Objective: Evaluate safety/onset of efficacy during titration of continuous subcutaneous apomorphine infusion (CSAI) for motor fluctuations in U.S. outpatients with Parkinson’s disease (PD). Background: Global…COPS: Continuous Observation of Parkinsonian Symptoms – A prospective data acquisition study using wearable accelerometery
Objective: To investigate the continuous and objective assessment of motor symptom severity in Parkinson’s Disease (PD) in everyday life. Background: Treatment adjustments in PD patients…Sympathetic tone abnormalities in subjects at risk for Parkinson’s Disease without evidence of nigrostriatal neurodegeneration: a multimodal biomarker study
Objective: To study autonomic dysfunction in subjects with idiopathic REM sleep behavior disorder (iRBD) and at least one pre-motor symptom of Parkinson's disease (PD). Background:…Role of bilateral pallidotomy in status dystonicus
Objective: The purpose of this study is to retrospectively review the results of bilateral pallidotomy in patients presenting with status dystonicus. Background: Dystonias, third commonest…DYT1 gene mutation: an atypical presentation with myoclonic dystonia
Objective: In the present work, we describe the case of a 54 years old man who presented a young-age onset (7-8 years old) of unilateral…Dorsolateral nigral hyperintensity on 1.5 versus 3T susceptibility-weighted magnetic resonance imaging in neurodegenerative parkinsonism
Objective: In contrast to their 1.5T counterparts, high field MRI scanners are often unavailable in clinical routine, particularly in primary care facilities and underserved regions.…A case of levodopa responsive parkinsonism due to methanol toxicity, an impact of COVID-19 crisis
Objective: To report the clinical course of secondary parkinsonism due to methanol toxicity with good levodopa responsiveness in the background of COVID-19 crisis. Background: The…Pilot case on the use of transcranial pulsed current stimulation(tPCS) in a patient with cervical dystonia(CD)
Objective: To demonstrate the efficacy of tPCS on a patient with CD Background: CD is a common adult-onset dystonia. Abnormal sensorimotor integration and maladaptive plasticity…White matter microstructural differences between essential tremor and Parkinson’s disease evaluated using advanced MRI biomarkers
Objective: To study white matter differences between essential tremor (ET) and Parkinson’s disease (PD) using standard diffusion tensor magnetic resonance imaging (DTI) and fixel-based analysis.…Funding and Sustainability Challenges in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease
Objective: The Edmond J Safra Accelerating Clinical Trials in Parkinson Disease (PD) initiative (EJS ACT-PD) aims to accelerate the identification of disease modifying treatment for…
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