Montelukast as disease modifying treatment for Parkinson’s disease: a pilot study.
Objective: To assess safety and tolerability of high dose Montelukast as a possible disease modifying treatment for Parkinson’s disease. Background: Emerging evidence suggests that the…Asymmetric synaptic density and glucose consumption in subjects with non-demented Parkinson’s Disease, as measured with [11C]UCB-J and [18F]FDG PET.
Objective: The objective of this study was to investigate asymmetric synaptic density and glucose consumption in moderate-stage non demented PD patients and the association between…Short-term effect of continuous positive airway pressure in MSA patients with sleep disordered breathing
Objective: SBD are frequent in MSA, mainly represented by inspiratory stridor, obstructive and central sleep apnea/hypopnea syndrome (SAS), or hypopneaimpacting the quality of sleep. A…Combined effect of polygenic background and GBA Pathogenic variants in Parkinson’s disease risk
Objective: We aimed to investigate whether polygenic background affects the penetrance of Parkinson’s disease (PD) among carriers of heterozygous pathogenic variants (PV) in GBA. Background: Several rare homozygous mutations within…Primary CNS Lymphoma presenting with Hemichorea Hemiballismus.
Objective: Completing the list of Hemichorea Hemiballismus apart from stroke and hyperglycaemic states. Background: 61years old female presented with subacute onset abnormal irregular purposeless movements…Fecal tyrosine decarboxylase and motor response complications in Parkinson’s Disease
Objective: To investigate the clinical correlates of gut microbe-derived tyrosine decarboxylase (tdc) and motor dysfunction in Parkinson’s Disease (PD) patients. Background: Gut microbe-derived tdc was…Depression in Parkinson’s disease is associated with subcortical neurodegeneration and increased risk of all-cause mortality and dementia
Objective: To evaluate the temporality, neuroanatomical correlates and prognostic significance of depression in PD using a large population cohort. Background: Depression may be an important…Freezing of gait in Parkinson’s disease with glucocerebrosidase mutations: prevalence, clinical correlates and effect on quality of life
Objective: Mutations in glucocerebrosidase (GBA) can change the phenotype of Parkinson’s disease (PD). This study aimed to explore the clinical characteristics of freezing of gait…Predicting ALS progression using remote sensor-based assessments
Objective: To develop a predictive model of amyotrophic lateral sclerosis (ALS) progression using self-administered digital assessments. Background: Remote fit-for-purpose sensor-based assessments stand to enhance the…Gut dysbiosis in Indian Parkinson’s Disease Patients with Constipation
Objective: To analyse the gut microbiome and explore dysbiosis in Indian Parkinson’s Disease patients with and without constipation. Background: Global studies have associated gut dysbiosis…
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