MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2022 International Congress

    Neurovascular and immune determinants of selective vulnerability of dopaminergic neurons in Parkinson’s Disease

    T. Balzano, N. Lopez Gonzalez-Del-Rey, N. Esteban-Garcia, A. Reinares-Sebastian, I. Trigo-Damas, JA. Pineda-Pardo, C. Cavada, JA. Obeso, J. Blesa (Mostoles, Spain)

    Objective: We aimed to investigate the contribution of glial cells activation and immune cells infiltration in the selective vulnerability of dopaminergic neurons within the midbrain…
  • 2022 International Congress

    Focused Ultrasound Subthalamotomy in Parkinson’s Disease: Lesion Topography and Motor Improvement.

    J. Mañez-Miro, R. Rodríguez-Rojas, J. Pineda-Pardo, M. Del álamo, R. Martinez-Fernandez, J. Obeso (MOSTOLES, Spain)

    Objective: To describe the topography of unilateral focused ultrasound (FUS) subthalamotomy in Parkinson’s disease (PD), and define correlations between lesion size/location and improvement of cardinal…
  • 2022 International Congress

    Subthalamic tremor-related oscillatory neurons play a role in the generation of Parkinson’s tremor

    P. Zhuang, M. Hallett, D. Meng, Y. Zhang, P. Li, J. Li (Beijing, China)

    Objective: To explore whether subthalamic tremor-related oscillatory neurons is involved in the generation of Parkinson’s tremor. Background: Both the basal ganglia and cerebello-thalamo-cortical circuits appear…
  • 2022 International Congress

    Postural tremors due to a cystic thalamic low-grade glioma treated by stereotactic aspiration

    M. Agrawal, S. Bhaskar, A. Arora, S. Panda, M. Garg, D. Jha (Jodhpur, India)

    Objective: To describe a rare case of contralateral postural tremors of the upper extremity as the only presenting complaint due to a thalamic solid cystic…
  • 2022 International Congress

    Medication safety in Parkinson’s disease patients: evaluation of recommendations for decision support in the national drug-disease interaction database

    JJ. de Jong, CCM. Stuijt, MME. Diesveld, T. van Laar, SD. Borgsteede (Groningen, Netherlands)

    Objective: Objective: Drug-disease interactions in Parkinson's disease patients can give rise to situations where a drug may have negative effects on both motor- and non-motor…
  • 2022 International Congress

    Pallidal Deep Brain Stimulation for Treatment of Poststroke Hemichorea

    D. Yoo, CK. Park, TB. Ahn (Seoul, Republic of Korea)

    Objective: We report a case of medication-refractory poststroke hemichorea where deep brain stimulation of the globus pallidus internus (GPi-DBS) was utilized to alleviate hemichorea. Background:…
  • 2022 International Congress

    Non-apoptotic caspase-3 activation mediates early synaptic dysfunction of indirect pathway neurons in the parkinsonian striatum

    C. Li, T. Fieblinger, E. Espa, MA. Cenci (Lund, Sweden)

    Objective: We set out to investigate whether caspase-3 plays a role in the loss of dendritic spines and the concomitant synaptic deficits that develop in…
  • 2022 International Congress

    Characterization of gastrointestinal dysfunction in Parkinson’s by disease stage

    M. Camacho, J. Greenland, D. Apostolopoulos, C. Daruwalla, C. Williams-Gray (Cambridge, United Kingdom)

    Objective: To conduct a comprehensive cross-sectional and longitudinal characterization of gastrointestinal dysfunction (GID) in Parkinson’s disease (PD). Background: GID is an important feature of PD…
  • 2022 International Congress

    Biochemical markers of glucocerebrosidase (GCase) deficiency in primary macrophages derived from GBA1 mutation carriers with and without Parkinson’s disease

    S. Pchelina, A. Kopytova, M. Nikolaev, A. Emelyanov, G. Baydakova, T. Usenko, A. Izymchenko, D. Bogdanova, K. Senkevich, I. Miliukhina, Y. Zakharova (Gatchina, Russian Federation)

    Objective: The aim of the present study was to assess biochemical markers in primary macrophages that could distinguish patient with Parkinson’s disease linked to mutations…
  • 2022 International Congress

    Improving the design of clinical trials in early-stage Parkinson’s disease by using the estimand framework

    J. Anzures-Cabrera, A. Monnet, G. Pagano (Welwyn Garden City, United Kingdom)

    Objective: To show how the estimand framework can be used to improve design of clinical trials testing treatments in early-stage Parkinson’s disease (PD). Background: The…
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