Preoperative Dyskinesia Impacts Postoperative Quality of Life in PD Patients with Subthalamic Deep Brain Stimulation
Objective: To evaluate postoperative quality of life (QoL) depending on the occurrence of dyskinesia during standardized levodopa test in patients with Parkinson’s Disease (PD) undergoing…Results from IRL790C005 – A Randomized, Double-Blind, Placebo-Controlled Phase IIb Study Evaluating the Efficacy of Mesdopetam on Daily On-Time without Troublesome Dyskinesia in Patients with Parkinson’s Disease
Objective: The objective of the Phase 2b-trial was to investigate efficacy and safety of three doses of Mesdopetam as adjunct treatment in patients with PD…From the Healthy Brain Ageing (HeBA) Cohort: Frequency of key risk factors for Parkinson in a European Cohort
Objective: To present the baseline data on common risk factors for Parkinson’s disease (PD) in the population-based cohort of the HeBA study (Ref Poster 1)…Human cerebellum contributes to the motor frequency coding for essential tremor and volitional rhythmic movements
Objective: Tremor and volitional rhythmic movement are frequency-specific motions. However, it remains unclear which area of the central nervous system can process frequency information. This…Agreement between swallow tail sign asymmetry and clinical laterality in Parkinson’s disease
Objective: Our goal was to evaluate the concordance between asymmetry in nigral hyperintensity detected with 3T MRI and clinical symptomatology. Background: A promising MRI marker…Quasi tandem repeat in TCERG1 may influence age at onset of X-linked dystonia-parkinsonism
Objective: To investigate whether the hexamer repeat in the TCERG1 gene plays a role in modifying disease onset in X-linked dystonia-parkinsonism (XDP). Background: Recently, it…Levodopa-Entacapone-Carbidopa Intestinal Gel in advanced Parkinson’s disease: a single center experience
Objective: To evaluate the efficacy of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIG) in achieving adequate control of motor complications in patients with advanced Parkinson’s Disease (APD). Background:…GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase shows evidence of pharmacological efficacy in an animal model of Parkinson’s disease.
Objective: To investigate the effect of the structurally targeted allosteric regulator GT-02287 on rotenone-induced neurotoxic effects in a Parkinson’s disease animal model. Background: Mutations in…Low Beta-Band Suppression as a Tool for DBS Contact Selection for Akinetic-rigid Symptoms in Parkinson’s Disease
Objective: To assess the utility of beta-band suppression as a tool for contact selection in patients undergoing nucleus subthalamicus (STN) deep brain stimulation (DBS) for…Bridging the Gap between Statistical significance and Clinical Relevance: A Systematic Review of Minimum clinically important difference (MCID) thresholds of scales reported in trials of Movement Disorders
Objective: To provide a comprehensive review of various patient-reported outcome (PROs) used in movement disorders (MD) research and their MCID values reported in literature. Background:…
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