Dopamine dysfunction in nigro-striatal pathway—multi-axial pathology in SCA 12
Objective: To assert pathophysiology in spinocerebellar ataxia type 12 (SCA12) extends way beyond cerebellar or spinal pathology. To further sensitise scientific community about consistent nigro-striatal…Identification of a Metabolic Brain Pattern Specific to Corticobasal Degeneration and Its Utility in Differential Diagnosis
Objective: To identify a metabolic brain pattern specific to corticobasal degeneration (CBD) and to develop a machine learning algorithm that can differentiate CBD from other…New machine learning approaches in tic detection: Seeking to learn more about the characteristic of tics
Objective: To develop a machine learning tool to distinguish between facial/head tics in people with Tourette syndrome and spontaneous movements in healthy controls. Background: Distinguishing…Chorea following SARS-CoV-2 infection and vaccination: a systematic review
Objective: We aimed to investigate and compare data on chorea following SARS-CoV-2 infection and vaccination to provide an extensive perspective on this pathology and to…Minimum clinically important difference (MCID) on the Unified Wilson Disease Rating Scale (UWDRS) Part III: results from the Phase 3 FoCus Trial
Objective: Minimum clinically important differences (MCID) on the Unified Wilson Disease Rating Scale (UWDRS) Part III were estimated using data from a phase III trial…Development of a health-related quality-of-life (HR-QoL) questionnaire for hereditary spastic paraplegia (HSP) patients and caregivers.
Objective: The aim of this project is to develop and validate a health-related quality-of-life (HR-QoL) questionnaire, in a patient and a caregiver version, specific for…Factors influencing health-related quality of life of patients with spinocerebellar ataxia
Objective: The objective was to demonstrate the progression of HRQoL over time and identify factors affecting SCA patients' HRQoL. Background: Spinocerebellar ataxias (SCA) comprise a…Computerized cognitive training in advanced Parkinson’s disease: preliminary feasibility data of an ongoing randomized controlled trial
Objective: To analyse the feasibility and effects on cognitive- and non-cognitive outcomes, and prediction of responsiveness of a computerized cognitive training (CT) in comparison to…Artificial intelligence for the improvement of imaging biomarkers in Parkinson’s disease
Objective: To systematically review the current literature on the application of artificial intelligence (AI) for imaging biomarkers in Parkinson's disease (PD) and to identify translational…Text entry as a digital outcome in Parkinson’s disease patients (TEXT-PD): results from two exploratory studies
Objective: To evaluate the feasibility and psychometric properties of text entry (TE) and touch metrics as digital outcomes for PD patients. Background: TE on smartphones…
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