Body-first and brain-first PD animal models mimic human PD subtypes
Objective: Here, we aim to model body- and brain-first PD by injecting pathology in the gut and amygdala of old wild-type rats, respectively. Background: Parkinson’s…Challenging diagnosis of familial Gerstmann-Straussler-Scheinker disease with normal brain image: a case report and systematic review
Objective: We report a case of familial Gerstmann-Straussler-Scheinker (GSS) disease, who presented with cerebellar ataxia, but did not show abnormalities in diffusion weighted image (DWI)…Study of retinal and optic nerve ganglion cell layer in Parkinson’s disease and asymptomatic carriers of the LRRK2-G2019S mutation
Objective: To study whether retinal nerve alterations can be a useful biomarker in presymptomatic stages of Parkinson's disease (PD) associated with the G2019S mutation of…COMBINED CSF α-SYN RT-QuIC, CSF NFL AND MIDBRAIN-PONS PLANIMETRY IN DEGENERATIVE PARKINSONISMS: FROM BEDSIDE TO BENCH, AND BACK AGAIN
Objective: (1) to assess the combined diagnostic ability of CSF NFL, CSF RT-QuIC α-SYN and midbrain/pons MRI measures in degenerative parkinsonisms; (2) to interpret results…An automated data cleaning approach to remove preparation artefacts from brain histology slide images
Objective: To present the potential application of an automated image analysis pipeline called WSIQC for the cleaning and quality assessment of brain histology images. Background:…Functional validation of a mitochondria-specific polygenic risk score in patient-based models for stratification of idiopathic Parkinson’s disease
Objective: The overall objective of this project is to gain essential knowledge on the contribution of genetic variability in nuclear-encoded mitochondrial proteins to idiopathic Parkinson’s…Caregiver burden and quality of life in late stage Parkinson’s disease
Objective: To describe and assess factors associated with informal caregiver quality of life (QoL) in late stage Parkinson’s disease (PD). Background: In the late stage…Optimizing patient-centric clinical outcome assessments for use in Parkinson’s disease clinical trials: Critical Path for Parkinson’s multistakeholder initiative
Objective: To advance patient-centric endpoints for use in early-stage Parkinson’s disease (PD) clinical trials. Background: Limitations with currently available patient-centric clinical outcome assessments (COAs) has…Cognitive Function in Late-life and Parkinson’s Disease Neuropathology at Death
Objective: To examine the association between cognitive function in late-life and Parkinson’s disease (PD) neuropathology at death, including 1) neuron loss in the locus coeruleus…Identifying meaningful symptoms and impacts of disease for patients with early Parkinson’s disease
Objective: To explore meaningful symptoms and impacts of disease on daily living in individuals with early-stage Parkinson’s disease (PD). Background: Critical Path for Parkinson’s (CPP)…
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