Audit of dysphagia care provided to Parkinson’s patients during acute hospital admission
Objective: To evaluate dysphagia recognition and management in Parkinson’s patients admitted to Royal Berkshire Hospital (RBH),Reading,UK according to National Confidential Enquiry into Patient Outcome and…CLINICAL AND GENEOLOGICAL FEATURES OF PARKINSON’S DISEASE
Objective: The initial purpose of the work is to study the clinical and genealogical features of Parkinson's disease. Background: Currently, clinical genetics has a number…Isolated ZIC4 antibody associated paraneoplastic cerebellar degeneration
Objective: Anti-ZIC4 antibodies have recently been associated with paraneoplastic cerebellar degeneration (PCD) and are usually associated with small cell carcinoma lung. However, most of the…Blood biomarkers and their association with non-motor symptoms in early Parkinson’s Disease
Objective: To identify if baseline blood biomarkers are associated with non-motor symptoms in early PD. Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with…Gait and Balance Characteristics in Atypical Parkinsonian Syndromes
Objective: To characterize a cohort of patients with multiple system atrophy (MSA) and progressive supranuclear gaze palsy compared to idiopathic Parkinson’s disease (IPD) patients according…Machine learning algorithms for classification and analysis of pen-on-paper Archimedes spirals
Objective: To classify tremor syndromes from freely hand drawn pen-on-paper Archimedes spirals using classical machine learning techniques. Background: Spiral drawings (Archimedean) are commonly used in…Mitochondrial and autophagy alteration in a new fatty acid hydroxylase-associated neurodegeneration (FAHN) model
Objective: Establishing a FAHN Drosophila model to identify cellular disease mechanisms. Background: Fatty acid hydroxylase-associated neurodegeneration (FAHN) is an early-onset neurodegenerative disease that manifests brain…Mutant WDR45 leads to altered ferroptosis in β-propeller protein-associated neurodegeneration
Objective: To functionally characterize WDR45-mediated BPAN (Beta-propeller protein-associated neurodegeneration). Background: BPAN patients usually present with global developmental delay and autistic features in early childhood and…Botulinum toxin injections are an effective treatment for patients with essential head tremor.
Objective: To assess the safety and efficacy of Botulinum toxin (Btx) injections in essential head tremor (HT) in a multicenter, randomized, double blind, parallel-group, placebo-controlled…A Phase 1b study to test the safety, pharmacokinetics, and pharmacodynamics of a novel inflammasome inhibitor in early-stage Parkinson’s disease: Rationale and study design
Objective: To describe the study design of a Phase 1b to test the safety, pharmacokinetics, and pharmacodynamics of a novel inflammasome inhibitor in individuals with…
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