Antidyskinetic Effects of CaV1.3 Calcium Channel Gene Silencing in Aged Male and Female Parkinsonian Macaques
Objective: To determine whether striatal CaV1.3 gene silencing ameliorates levodopa-induced dyskinesias (LID) in the preclinical gold-standard non-human primate (NHP) model without altering levodopa’s antiparkinsonian benefit.…Gerstmann-Straussler-Scheinker Syndrome Manifesting Levodopa-Responsive Parkinsonism, Levodopa-Induced Dyskinesia, and Abnormal DaT-SPECT
Objective: The objective of this report is to describe previously unreported features in a patient with Gerstmann-Straussler-Scheinker syndrome (GSS) due to the F198S mutation. Background:…Throat Clearing tics In Wilson’s Disease- An Unusual Manifestation
Objective: To report unusual presentation of throat clearing tics in a 15 year old Indian girl with Wilson’s disease (WD). Background: WD is one of…Prevalence, clinical and neuropsychiatric aspects of Sleep Disorders in Parkinson’s disease: a meta-analysis
Objective: The present meta-analysis aims to provide a reliable estimate of the prevalence and associated clinical and neuropsychiatric aspects of the most frequent sleep disorders…Association of creaky voice with motor severity in Parkinson’s disease using an automated algorithm.
Objective: We characterized creaky voice in Parkinson’s disease (PD) and evaluated the association of this acoustic phenomenon with motor and cognitive status. Background: Creaky voice (“vocal fry”)…The development of a screening tool to identify movement disorders in patients with inborn errors of metabolism
Objective: To develop a user-friendly rapid screening tool for non-movement disorder specialists to detect movement disorders in patients with inborn errors of metabolism. Background: Movement…Psychiatric evaluation according to Brief Psychiatric Rating Scale-Expanded in patients with Parkinson’s disease
Objective: The aim of the study was to evaluate psychiatric manifestations of Parkinson’s disease (PD) and to establish statistical links with sociodemographic and clinical PD…Parkinson’s Disease and Psychosocial Impact: Anxiety, Depression and Positive Symptoms
Objective: Explore the relationship between patient self-reported assessment of positive symptoms, depression, and anxiety in PwPD. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder…Improving the patient self-awareness of the first motor fluctuations in early Parkinson’s disease with a wearable sensor
Objective: We aim to assess if the use of a wearable sensor can increase the patient and caregiver self-awareness of the first motor fluctuations (MF).…The benefit of exclusive nocturnal administration of a levodopa-carbidopa intestinal infusion for severe refractory sleep behavior disorder in Parkinson’s disease
Objective: Treatment by continuous diurnal intestinal infusion of levodopa is effective in improving sleep quality in Parkinson's disease (PD), but its use exclusively at night…
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