Estimating the Meaningful Within-Patient Change Threshold for the MDS-UPDRS Part III
Objective: To estimate the meaningful within-patient worsening threshold (MWPWT) of the Movement Disorders Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS Part III in early-stage Parkinson's disease…Illusion of semi-inverted posture during High Frequency Ultrasound Stimulation thalamotomy for tremor
Objective: In this study, we focused on the transient sensation of being tilted along the vertical axis during MRI-guided focused ultrasound (MRgFUS) for tremor. We…Gene Expression Quantification to Assess Frataxin Replacement Therapies in Friedreich’s Ataxia
Objective: To identify genetic disease and efficacy markers for Friedreich’s ataxia (FRDA) Background: FRDA is a genetic disease caused by decreased expression of the mitochondrial…Atypical parkinsonism related to a rare variant in the PLA2G6 gene
Objective: To describe a patient with atypical parkinsonism, carrier of a rare PLA2G6 gene variant. Background: PLA2G6-associated neurodegeneration (PLAN) results from mutations in PLA2G6 gene…“Mirror” jaw movements in parkinsonian patients
Objective: To describe synchronous involuntary rhythmic jaw movements during voluntary hand movements in parkinsonian patients. We called them "mirror" jaw movements. Background: Mirror movements (MM)…Measuring functional cognition with the Short Weekly Calendar Planning Activity in patients with Parkinson’s disease and non-manifesting LRRK2 and GBA carriers
Objective: The aims of this study were to explore the feasibility of the short Weekly Calendar Planning Activity (WCPA-10) to investigate functional cognition in patients…Impact of two different rechargeable pulse generators on parkinsonian patients with deep brain stimulation
Objective: This study compared the recharging frequency and duration, perceived impact and self-management of recharging, and motor symptom suppression in fifteen PD patients who underwent…MRI biomarkers of freezing of gait development in in Parkinson’s disease
Objective: This study investigated longitudinal clinical, structural and functional brain alterations in Parkinson’s disease patients with freezing of gait (PD-FoG) and in those developing (PD-FoG-converters)…Motor-Related and Cognition-Related Safety of Pimavanserin in Patients with Parkinson’s Disease Psychosis (PDP)
Objective: Evaluate motor- and cognition-related safety in pimavanserin-treated patients with PDP. Background: Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, is the only US FDA-approved treatment for…Paliperidone induced neuroleptic malignant syndrome treated with electroconvulsive therapy and continuous apomorphine: A case report
Objective: Neuroleptic malignant syndrome (NMS) is a neurological emergency that is often induced by antipsychotic drugs. NMS may be mortal if left untreated. Background: In…
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