Acute administration of methylphenidate modulates functional connectivity during the processing of irrelevant stimuli in Parkinson’s disease patients
Objective: Examine the effects of a single dose of methylphenidate (MPD), on event-related functional connectivity (FC), in patients with Parkinson’s disease (PD). Background: Recent studies…Sleep Circadian Rhythms and Brain Disorders: A Large Prospective Cohort and Mendelian randomization Study
Objective: This study aims to investigate the causal relationship between disruptions in sleep circadian rhythms and the risk of seven brain disorders. Background: Disruptions in…Dietary and Environmental Risk Factors of Parkinson’s Disease: An Integrated Network Pharmacology Approach
Objective: To investigate dietary and environmental determinants of Parkinson’s disease (PD) and related mortality by integrating large-scale clinical phenotyping with network pharmacology and molecular docking…A Longitudinal Case of Adult-Onset Progressive Ataxia in a Patient with a Pathogenic Variant of IRF2BPL
Objective: To describe the course of a patient with an inherited IRF2BPL variant presenting as adult-onset indolent ataxia and tremor with no prior developmental abnormalities,…The GLP-1 Agonist Paradox in Parkinson’s Disease: A Comparative Analysis of Lixisenatide and Exenatide Phase III Trial Outcomes and Neuroprotective Mechanisms
Objective: To assess the pharmacological and methodological factors underlying the "GLP-1 paradox" by comparing the outcomes of lixisenatide and exenatide, with an emphasis on kinetics,…Beyond Parkinson’s Disease, Impulse Control Dysregulation: The Psychosocial Correlates of Problematic Internet Use
Objective: To determine the prevalence of problematic internet use and associated psychosocial correlates as a phenotype of impulse control dysregulation among undergraduates. Background: Impulse control…One day accelerated 10 Hz rTMS for Focal Hand Dystonia: A Phase II Clinical Trial
Objective: To evaluate the efficacy of four sessions of 10 Hz repetitive transcranial magnetic stimulation delivered in one day (rTMS) to patients with focal hand…Cognitive Progression in Elderly Essential Tremor Patients: Evidence from an 18-Month Prospective Cohort
Objective: Essential tremor (ET) is one of the most prevalent neurological disorders and has increasingly been linked to cognitive dysfunction. However, most existing data regarding…Micro- and Nanoplastics in Parkinson’s Disease Pathogenesis An Emerging Environmental Risk Factor
Objective: To synthesize current experimental and translational evidence supporting the hypothesis that micro- and nanoplastics (MNPs) may contribute to Parkinson’s disease (PD) pathogenesis through neuroinflammatory…Proposal of Anatomo-Functional Tremor Patterns for Ultrasound-Guided Botulinum Toxin Infiltration
Objective: To propose a practical anatomo-functional framework for ultrasound-guided BoNT-A infiltration in upper limb tremor based on tremor biomechanics. Background: Botulinum toxin type A (BoNT-A)…
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