Natural History of Sialidosis Type I: A Prospective Longitudinal Follow-Up Study of Clinical and Electrophysiological Markers
Objective: We performed a prospective analysis to determine the natural history as well as changes of electrophysiological markers in a cohort of Sialidosis type I.…Clinical and Genetic Profile of the ACTIVATE Population: A Phase 2 Trial of BIA 28-6156 in GBA-PD
Objective: To characterize the patient population enrolled in the ACTIVATE study, a Phase 2 multicenter, randomized, double-blind, placebo-controlled trial assessing the efficacy, safety, tolerability, pharmacodynamics,…Basal Ganglia Hypointensity Associated with Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS)
Objective: To present a new case of glucose transporter type 1 deficiency syndrome (GLUT1-DS) diagnosed in adulthood and to describe the associated radiological findings. Background:…Dopamine Receptor Blocking Drug Exposure is Associated with Parkinson’s Disease
Objective: To test the hypothesis that dopamine receptor blocking agents (DRBAs) contribute to the later diagnosis of Parkinson’s disease (PD). Background: Recent evidence suggests that…Neuroimaging-guided automated optimization of deep brain stimulation in Parkinson’s disease: preliminary results
Objective: To evaluate the clinical impact of an automated neuroimaging-guided optimization algorithm (Illumina™, Boston Scientific) for programming in patients with suboptimal response to subthalamic nucleus…Increased Pre-Alpha EEG Functional Connectivity Forecasts Future Cognitive Decline in Parkinson’s Disease
Objective: To evaluate whether resting-state EEG functional connectivity (rsEEG-FC) forecasts cognitive decline three years later in Parkinson’s disease (PD). Background: Cognitive performance and trajectories of…Multimodal Gait Analysis Using Video Pose Estimation Deep Learning and Walkway Parameters: Parkinsonism Detection and Phenotyping
Objective: To develop a multimodal framework fusing frontal-view video pose estimation frame coordinates with pressure-sensitive walkway features for parkinsonism detection, and to discover clinically meaningful…The ORCHESTRA Study Year 2: Practical Experiences With Foslevodopa/Foscarbidopa Treatment in Advanced Parkinson’s Disease in a Real-World Setting
Objective: To describe real-world learnings on the routine practical management of foslevodopa/foscarbidopa (LDp/CDp), a continuous 24-hour subcutaneous infusion therapy for advanced Parkinson’s disease (aPD), using…Beyond the Brain: Resting Tremor as a Presentation of Cervical Spinal Schwannoma
Objective: Tremor is classically attributed to abnormalities within supraspinal motor circuits, most commonly the cerebellum, thalamus, red nucleus or basal ganglia and rarely considered a…Automated Video-Based Assessment of Lip Articulation in Parkinson’s Disease
Objective: To investigate whether automated video-based analysis of lip articulation can capture speech-relevant changes in the orofacial system in Parkinson’s disease (PD) and to determine…
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