Impulse control disorder following bilateral pallidothalamic tract focused ultrasound: a case report
Objective: Description of a case of ICD following non-contemporaneous bilateral pallidothalamic focused ultrasound tractotomy. Background: Impulsive and compulsive behaviours in PD are hypothesized to largely…Does needle size matter in botulinum toxin injection? A crossover randomised controlled trial of microneedle in patients with hemifacial spasm
Objective: The aim of this study was to compare the severity of pain and bruises between a microneedle (34-G) and standard needle (30-G) in patients…NIMHANS Neuropsychological Battery for Elderly in Parkinson’s disease patients: Validation and diagnosis using MDS PD-MCI task force criteria in Indian population
Objective: To validate NIMHANS Neuropsychological Battery for Elderly( NNB-E) and evaluate cognitive impairment in Parkinson's disease (PD) patients in comparison with healthy controls. Background: Cognitive…Real-world evidence and feasibility of telemedicine for Parkinson’s disease
Objective: This work aims to provide real-world evidence for the feasibility of telemedicine in Parkinson’s disease (PD). Adherence data presented pertain to patients paying out…High-beta Oscillations Predict Outcome of Subthalamic Deep Brain Stimulation in Parkinson’s Disease
Objective: We evaluated whether low-β and high-β band activity recorded from the subthalamic nucleus (STN) region predicts efficacy of deep brain stimulation (DBS) in Parkinson's…Whole exome sequencing identifies novel variants underlying Ataxia with Oculomotor Apraxia type 1 in Pakistani consanguineous families
Objective: To investigate the underlying pathogenic variants in four consanguineous Pakistani families segregating Ataxia with Oculomotor Apraxia type 1 Background: Ataxia with Oculomotor Apraxia type 1…Neural and cognitive correlates of the co-occurrence of apathy and Impulse Control Disorder in early Parkinson’s Disease
Objective: The present study aims to explore the co-occurrence of impulse control disorder (ICD) and apathy and its neural correlates analyzing anatomical changes in gray…Exenatide protects iPSC-derived dopaminergic neurons with A53T mutation through restoration of insulin signaling
Objective: Here we sought to investigate mechanisms by which insulin resistance affects PD pathogenesis in-vitro, and whether restoration of insulin signaling, using GLP-1 agonist exenatide…Overnight stimulation: a new rescue strategy for deep brain stimulation-induced bradykinesia in dystonia?
Objective: We report the serendipity case of overnight stimulation for the management of stimulation-induced bradykinesia in two patients with generalized dystonia and clinically-effective pallidal deep…The anti-alpha-synuclein antibody Lu AF82422 was safe and well tolerated in a FIH-SAD study in healthy subjects and patients with PD
Objective: Evaluation of safety, tolerability, pharmacokinetics (PK) and target engagement (TE) in healthy subjects (HS) and patients with Parkinson’s disease (PD) following single ascending doses…
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