White matter and subcortical volume of essential tremor patient decreases after MR-guided focused ultrasound thalamotomy
Objective: To study the anatomic volume differences of essential tremor (ET) patient before and after MR-guided focused ultrasound (MRgFUS) thalamotomy using respective 3D T1-weighted MR…Identification and Characterization of Selective and High Affinity Small Molecules as Positron Emission Tomography (PET) Imaging Tracers for Pathological Alpha-Synuclein
Objective: The aim is to develop small molecular weight compounds which bind selectively and with high affinity to alpha-synuclein (a-syn) aggregates as diagnostic PET imaging…The Dutch Parkinson and Cognition study (DUPARC): Cognitive impairment and cholinergic innervation in de novo Parkinson’s Disease patients
Objective: To explore the incidence and characteristics of early cognitive impairment in Parkinson’s disease (PD) patients and the relationship with regional cholinergic innervation. Background: Cognitive…Neuroimaging in Parkinson’s disease dementia: Connecting the dots
Objective: To identify the neural substrates of Parkinson’s disease dementia (PDD) and Parkinson’s disease with Mild Cognitive Impairment (PD-MCI) using a network mapping approach. Background:…Evaluation of Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s Disease: An in vivo [11C]BU99008 PET study
Objective: We aimed to evaluate the role of astroglia activation in Parkinson's disease (PD) using [11C]BU99008 PET, a novel radioligand with high specificity and selectivity…Evaluation of Imidazoline 2 binding sites reflecting astroglia pathology in Huntington’s Disease: An in vivo [11C]BU99008 PET study
Objective: We aimed to evaluate the role of astroglia activation in Huntington’s disease gene expansion carriers (HDGECs) using [11C]BU99008 PET, a novel radioligand with high specificity and…The role of Synaptic vesicle protein 2A (SV2A) in patients with Parkinson’s disease dementia and Dementia with Lewy bodies: An in vivo [11C]UCB-J PET study
Objective: We aimed to investigate the role of synaptic vesicle glycoprotein 2A (SV2A) in Parkinson’s disease dementia (PDD) and Dementia with Lewy bodies (DLB) using…Regional subcortical volumes predict gait decline in early Parkinson’s disease
Objective: To predict changes in discrete gait characteristics in early Parkinson’s disease (PD) compared to healthy ageing, using subcortical brain volumes quantified in early disease.…Distributed Global Functional Connectivity Networks Predict Responsiveness to L-DOPA and Subthalamic Deep Brain Stimulation
Objective: To investigate global resting-state functional connectivity (rsFC) patterns associated with response to L-DOPA and to subthalamic nucleus (STN) deep brain stimulation (DBS) in patients…The neural representations of the voice tremor spectrum
Objective: Investigate shared and disorder-specific brain abnormalities in essential and dystonic tremor of voice using functional and structural brain imaging. Background: Essential tremor of voice…
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