Investigating Phospho-α-Synuclein Pathology in Patient-Specific Microglia Integrated into Midbrain Organoids
Objective: This study aims to determine how patient-specific microglia influence phospho-α‑synuclein aggregation and contribute to disease-relevant phenotypes within human midbrain organoids. Background: Parkinson’s disease (PD)…Posterior tibial nerve Stimulation in the management of Urinary Disorders in Parkinson’s Disease Experience of the National Hospital Center of Pikine
Objective: Evaluate the efficacy of posterior tibial nerve stimulation in the management of LUTS in patients with PDCompare posterior tibial nerve stimulation to medication Background:…Vocal Tremor as the Initial Manifestation of Palatal Tremor with Response to Propranolol : A Case Report
Objective: To describe an unusual presentation of essential palatal tremor manifesting as vocal tremor and to discuss its diagnostic considerations and therapeutic response to propranolol.…Mechanisms of PLA2G6 Deficiency Impacting Mitochondria-associated membranes in Parkinson’s Disease
Objective: This study aims to explore the functions of PLA2G6 protein at the endoplasmic reticulum-mitochondria interface, unveiling the potential mechanisms of PLA2G6-related Parkinson’s disease (PD)…Exploring the Causal Role of Mitochondria-related Genes in Parkinson’s Disease through Multi-Omics Mendelian Randomization
Objective: To investigate the causal roles of mitochondria-related gene expression in the pathogenesis of Parkinson's Disease (PD). Background: Mitochondria-related gene expression has been implicated in…Single centre experience with subcutaneous foslevodopa/foscarbidopa for GBA Parkinson’s disease
Objective: To describe the clinical outcomes of two patients with GBA Parkinson’s disease (GBA-PD) and severe motor fluctuations treated with subcutaneous foslevodopa/foscarbidopa (fld/fcd) infusion. Background:…Cerebellar Network Compensation in Parkinson’s Disease: Functional Connectivity Across Motor and Cognitive Circuits
Objective: To investigate whether alterations in cerebellar connectivity with cortical and basal ganglia networks in Parkinson’s disease (PD) represent compensatory network adaptations related to dopaminergic…Kinetic–rest tremor polarity for differentiating dystonic tremor and Parkinson’s disease
Objective: To characterize ordinal patterns of tremor amplitude across rest, postural, and kinetic conditions in dystonic tremor (DT) and Parkinson's disease (PD) using accelerometry, and…Beyond Freezing of Gait Episodes in Parkinson’s Disease: Intercritical Kinematic Gait Pattern Matters.
Objective: To search for features discriminating different gait patterns during intercritical FOG-free phases in patients with anamnestic FOG, using spatiotemporal and kinematic variables and machine…Efficacy and Safety of Mesdopetam (IRL790) for Levodopa Induced Dyskinesia in Parkinson’s Disease: A Meta analysis of Randomized Controlled Trials
Objective: To evaluate the efficacy and safety of mesdopetam compared with placebo for levodopa‑induced dyskinesia (LID) in Parkinson’s disease (PD). Background: Mesdopetam (IRL790) is a…
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