Repurposing Rifabutin for Neuro-Metabolic Disorders: AMPK-PGC-1α-Driven Mitochondrial Protection in Diabetes Associated Parkinsonism
Objective: To assess the role of rifabutin in restoring mitochondrial function and energy balance through modulation of the AMPK–PGC-1α signaling pathway in diabetes-related Parkinsonism. Background:…Irisin as a Molecular Mediator of Exercise Induced Neuroprotection and Disease Modification in Parkinson’s Disease
Objective: To integrate mechanistic evidence delineating irisin mediated molecular pathways relevant to Parkinson’s disease (PD) pathogenesis and neuroprotection, focusing on α-syn clearance, autophagy–lysosomal function, mitochondrial…Community Gym Exercise Therapy for People Living with Early Onset Parkinson’s Disease
Objective: To understand the experiences of people living with early onset Parkinson’s disease (EOPD) and exercise trainers regarding the safety, feasibility, acceptability and perceived benefits…Efficacy of Novel Antipsychotic Agents on Cognitive Functions in Parkinson’s Disease: A Systematic Review and Meta-analysis of 2,533 Patients
Objective: To systematically evaluate and quantitatively synthesize evidence on the effects of novel antipsychotic agents (Clozapine, Olanzapine, Risperidone, and Aripiprazole) on cognitive domains in Parkinson’s…Urate Levels and Risk of Parkinson’s Disease：A Two-Sample Mendelian Randomization Study
Objective: To investigate the causal relationship between circulating serum urate levels and the risk of Parkinson's disease (PD) using a two-sample Mendelian randomization (MR) approach.…Micro- and Nanoplastics in Parkinson’s Disease Pathogenesis An Emerging Environmental Risk Factor
Objective: To synthesize current experimental and translational evidence supporting the hypothesis that micro- and nanoplastics (MNPs) may contribute to Parkinson’s disease (PD) pathogenesis through neuroinflammatory…Diet Quality and Nutrient Intake in Parkinson’s Disease: A Multicenter Study in Egypt
Objective: To compare diet quality and nutrient intake between PD patients and controls and examine associations with PD clinical features. Background: Parkinson’s disease (PD) is…Clinical Characteristics and Functional Impact of Tremor in Patients with Multiple Sclerosis in Nepal: A Cross-Sectional Observational Study
Objective: To describe the clinical characteristics of tremor in multiple sclerosis (MS) patients in Nepal and assess its functional impact on daily living. To describe…The Correlation Between Serum Uric Acid Levels And The Severity Of Parkinson’s Disease
Objective: This study aims to analyze the correlation between serum uric acid levels and the severity of Parkinson's disease. Background: Uric acid has been implicated…Quantitative Analysis of Oculomotor Abnormalities in Parkinson’s Disease
Objective: To quantitatively characterize oculomotor abnormalities in patients with Parkinson’s disease (PD) and to evaluate their potential utility for assessing oculomotor dysfunction and supporting early…
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