Biochemical and Nutritional Changes During Continuous Subcutaneous Apomorphine Infusion in Advanced Parkinson’s Disease: Findings from an Observational Cohort
Objective: To evaluate the clinical effectiveness of CSAI and associated changes in vitamin B status, homocysteine (Hcy) levels, and nutritional outcomes in patients with advanced…Effects of Manual Therapy on Hand Dexterity in Children Aged 4–8 Years: A Prospective Interventional Study
Objective: This study aimed to evaluate the effect of a structured manual therapy program on hand dexterity in young children. Background: Impaired hand dexterity is…7 Tesla MRI with Quantitative Susceptibility Mapping: Quantitative focal measurements and qualitative grading of the substantia nigra as a biomarker for Parkinson’s Disease
Objective: To quantitatively and qualitatively evaluate susceptibility changes in the dorsal SN (dSN), using quantitative susceptibility mapping (QSM) and susceptibility-weighted imaging (SWI) at 7Tesla (7T)…Hip fractures in Parkinson’s Disease: A single-centre retrospective cohort study
Objective: Evaluate hip fracture (NOF) management in Parkinson's (PD) against National Institute of Clinical Excellence (NICE) guidelines to identify if adverse outcomes arise from differences…Sleep Disorders and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To comprehensively evaluate the association between various sleep disorders and the risk of developing Parkinson’s disease. Background: Sleep disturbances are increasingly recognized as important…Ante-Mortem Motor Speech Profiles in Postmortem Confirmed Atypical Parkinsonisms
Objective: Differences in motor speech profiles may aid in diagnosis of atypical parkinsonisms. This is a retrospective study that characterizes ante-mortem motor speech profiles in postmortem…Topographic Heterogeneity of Dopaminergic Denervation and Iron Deposition in Functional Subregions of Nigrostriatal System in Parkinson’s Disease
Objective: To investigate the spatial relationship between striatal dopaminergic denervation and nigral iron accumulation in Parkinson’s disease (PD) using functional subregional parcellation. Background: Excessive nigral…Cannabis-based Oil for Pain and Other Non-motor Symptoms in Parkinson’s Disease: a Randomized Controlled Trial
Objective: To assess the safety, tolerance, and effectiveness of an oil extract of Cannabis sativa L. on pain and other non-motor symptoms (NMS) in people…The Impact of Demographic Factors on Skull Density Ratios in a Hawaii Cohort
Objective: To understand the impact of demographic factors on skull density ratio (SDR) in Hawai‘i patients. Background: SDR is a validated indicator of the ability…Investigating Phospho-α-Synuclein Pathology in Patient-Specific Microglia Integrated into Midbrain Organoids
Objective: This study aims to determine how patient-specific microglia influence phospho-α‑synuclein aggregation and contribute to disease-relevant phenotypes within human midbrain organoids. Background: Parkinson’s disease (PD)…
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