Evaluating Bradykinesia in Parkinson’s Disease: Added Value of Monitoring Passive Arm Movement with a Wrist-Worn Wearable Sensor
Objective: To evaluate the reliability and validity of passively monitored arm movements as an approximate measure of bradykinesia. Background: Clinical assessment of bradykinesia in Parkinson’s…Homozygous PRRT2 Frameshift Mutation Presenting with Infantile Onset Seizures and Childhood Episodic Ataxia
Objective: To report a rare presentation of a homozygous PRRT2 frameshift mutation manifesting as infantile-onset seizures followed by childhood episodic gait imbalance. Background: PRRT2 mutations…Sleep Slow-Wave Activity Topography and Dynamics in PD: Relationships with Resting-State fMRI data and Glymphatic Clearance
Objective: We propose that abnormal EEG power dynamics during sleep are associated not only glymphatic dysfunction but also signal fundamental changes in resting-state functional connectivity…Do Digital Mobility Outcomes Differ Across Clinically Defined NSD-ISS Stages in Parkinson’s Disease?
Objective: To determine whether digital mobility outcomes (DMOs) differ between individuals with relatively advanced PD grouped according to the clinical criteria of the Neuronal α-Synuclein…Efficacy and Safety of Ecopipam for Tourette Syndrome: A Meta analysis of Controlled Trials
Objective: To evaluate the efficacy and safety of ecopipam for tic reduction in Tourette syndrome (TS). Background: Ecopipam, a selective dopamine D1 receptor antagonist, has…Social Network Structure and Caregiving Experiences in South Asian Families Living with Dementia Associated with Parkinsonian Disorders
Objective: To characterize social network structure and caregiving among SA families with Parkinsonian dementia (PD) and compare them with White American (WA) caregiving networks. Background:…Harnessing the Local Wisdom of Central Kalimantan’s Eleutherine palmifolia (Dayak Onion) in Parkinson’s Disease Therapy: A Molecular Docking and Ethnopharmacological Study”
Objective: The purpose of this in silico study was to examine the potential protective effects of chemicals found in dayak onion against PD Background: Dayak…Biochemical and Nutritional Changes During Continuous Subcutaneous Apomorphine Infusion in Advanced Parkinson’s Disease: Findings from an Observational Cohort
Objective: To evaluate the clinical effectiveness of CSAI and associated changes in vitamin B status, homocysteine (Hcy) levels, and nutritional outcomes in patients with advanced…Effects of Manual Therapy on Hand Dexterity in Children Aged 4–8 Years: A Prospective Interventional Study
Objective: This study aimed to evaluate the effect of a structured manual therapy program on hand dexterity in young children. Background: Impaired hand dexterity is…7 Tesla MRI with Quantitative Susceptibility Mapping: Quantitative focal measurements and qualitative grading of the substantia nigra as a biomarker for Parkinson’s Disease
Objective: To quantitatively and qualitatively evaluate susceptibility changes in the dorsal SN (dSN), using quantitative susceptibility mapping (QSM) and susceptibility-weighted imaging (SWI) at 7Tesla (7T)…
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