Exploratory Quantitative Gait Analysis for Differentiating Parkinson’s Disease from Atypical Parkinsonian Syndromes
Objective: To compare quantitative spatiotemporal and plantar pressure gait parameters between patients with Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS) using instrumented gait analysis.…Patient Perspectives on Telemedicine and Remote Deep Brain Stimulation Programming in Parkinson’s Disease: A Questionnaire Survey
Objective: To identify unmet needs in deep brain stimulation (DBS) programming among patients with Parkinson’s disease (PD) in Japan by assessing outpatient burden and patient…An Ongoing Phase 1/2, Multi-center, Open Label Study of NouvNeu001 for the Treatment of Advanced Parkinson’s Disease
Objective: This ongoing, phase 1/2, multi-center, open label study aims to evaluate the safety, tolerability, and efficacy of NouvNeu001 (NCT#06167681) for treating mid to late-stage…Extended long-term follow-up of adaptive deep brain stimulation in Parkinson’s disease
Objective: To evaluate the extended long-term durability, programming stability, and safety of adaptive deep brain stimulation (aDBS) in people with Parkinson’s disease (PD). Background: Adaptive DBS is a recently available enhancement to continuous DBS (cDBS) that dynamically adjusts stimulation amplitude based on neural…Substantia Nigra Free-Water, Metabolic Markers, and Motor Variability in Older Adults with Diabetes
Objective: To examine whether nigral microstructural integrity measured via substantia nigra free-water MRI (FW-MRI) relates to peripheral metabolic burden and motor variability across the glycemic…Evaluating YouTube as a source of health information on Parkinson’s disease
Objective: This study aimed to evaluate the quality, reliability, and engagement characteristics of YouTube videos on Parkinson's disease using standardized assessment tools. Background: Parkinson’s disease…Evaluating Bradykinesia in Parkinson’s Disease: Added Value of Monitoring Passive Arm Movement with a Wrist-Worn Wearable Sensor
Objective: To evaluate the reliability and validity of passively monitored arm movements as an approximate measure of bradykinesia. Background: Clinical assessment of bradykinesia in Parkinson’s…Homozygous PRRT2 Frameshift Mutation Presenting with Infantile Onset Seizures and Childhood Episodic Ataxia
Objective: To report a rare presentation of a homozygous PRRT2 frameshift mutation manifesting as infantile-onset seizures followed by childhood episodic gait imbalance. Background: PRRT2 mutations…Sleep Slow-Wave Activity Topography and Dynamics in PD: Relationships with Resting-State fMRI data and Glymphatic Clearance
Objective: We propose that abnormal EEG power dynamics during sleep are associated not only glymphatic dysfunction but also signal fundamental changes in resting-state functional connectivity…Do Digital Mobility Outcomes Differ Across Clinically Defined NSD-ISS Stages in Parkinson’s Disease?
Objective: To determine whether digital mobility outcomes (DMOs) differ between individuals with relatively advanced PD grouped according to the clinical criteria of the Neuronal α-Synuclein…
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